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02.06.2022

Measuring photophysical transition rates with fluorescence correlation spectroscopy and antibunching

Authors Sakhapov D, Gregor I, Karedla N, Enderlein J Journal Journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2022 Jun 2;13(21):4823-4830. Abstract We present a new method that combines fluorescence correlation spectroscopy (FCS) on the microsecond time scale with fluorescence antibunching measurements on the nanosecond time scale for
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02.06.2022

The relevance of synuclein autoantibodies as a biomarker for Parkinson’s disease

Authors Garg P, Maass F, Sundaram SM, Mollenhauer B, Mahajani S, van Riesen C, Kügler S, Bähr M Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2022 Jun 2:103746. Abstract Several studies have investigated if the levels of α-synuclein autoantibodies (α-syn AAb) differ in serum of Parkinson’s disease (PD)
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02.06.2022

Resolving the molecular architecture of the photoreceptor active zone by 3D-MINFLUX

Authors Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T Journal Science Advances Citation Sci Adv. 2022 Jul 15;8(28):eabl7560. Abstract Cells assemble macromolecular complexes into scaffoldings that serve as substrates for catalytic processes. Years of molecular neurobiology indicate that neurotransmission depends on such
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01.06.2022

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

Authors Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A Journal eBioMedicine Citation EBioMedicine. 2022 Jun;80:104021 Abstract Background: Synucleinopathies such as Parkinson ́ s disease
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01.06.2022

Statistical Methods for Minimax Estimation in Linear Models with Unknown Design Over Finite Alphabets

Authors Behr M, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 4(2):490-513. Abstract We provide a minimax optimal estimation procedure for F and W in matrix valued linear models Y = F W + Z where the parameter matrix W
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31.05.2022

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed
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27.05.2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Authors Xiong L, Tolen EA, Choi J, Velychko S, Caizzi L, Velychko T, Adachi K, MacCarthy CM, Lidschreiber M, Cramer P, Schoeler HR Journal eLife Citation eLife 11:e71533. Abstract The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not
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27.05.2022

Remote control of the heart and beyond

Authors Zimmermann WH Journal Science Citation Science. 2022 May 27;376(6596):917-918. Abstract A resorbable closed-loop sensor-actuator implant can temporarily control heart rate. DOI 10.1126/science.abq0605 Pubmed Link  
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26.05.2022

Excited state lifetime modulation in semiconductor nanocrystals for super-resolution imaging

Authors Ghosh S, Hollingsworth JA, Gallea JI, Majumder S, Enderlein J, Chizhik AI Journal Nanotechnology Citation Nanotechnology. 2022 Jun 15;33(36). Abstract We report on proof of principle measurements of a concept for a super-resolution imaging method that is based on excitation field density-dependent lifetime modulation of semiconductor nanocrystals. The prerequisite
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25.05.2022

Electrically Controlling and Optically Observing the Membrane Potential of Supported Lipid Bilayers

Authors Yudovich S, Marzouqe A, Kantorovitsch J, Teblum E, Chen T, Enderlein J, Miller EW, Weiss S Journal Biophysical Journal Citation Biophys J. 2022 May 25:S0006-3495(22)00430-1 Abstract Supported lipid bilayers are a well-developed model system for the study of membranes and their associated proteins, such as membrane channels, enzymes, and
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