Outeiro, Tiago Fleming

Authors Koss DJ, Erskine D, Porter A, Palmoski P, Menon H, Todd OGJ, Leite M, Attems J, Outeiro TF Journal Acta Neuropathologica Communications Citation Acta Neuropathol Commun. 2022 Jul 6;10(1):98. Abstract Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (aSyn) within neurons in the

Authors Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO Journal Protein Science Citation Protein Sci. 2022 Jul;31(7):e4360. Abstract Recent studies revealed that molecular events related with the physiology

Authors Domingues R, Sant’Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2022 Jun 15;168:105696. Abstract Synucleinopathies are a group of progressive neurodegenerative diseases known for the accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn). Recently, it has been assumed

Authors Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 May 14:ddac104. Abstract Parkinson’s disease (PD) is a neurological disorder with complex interindividual etiology that is

Authors Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. Abstract Alpha-synuclein (aSyn) is a central

Authors Ding Y, Korchak S, Mamone S, Jagtap AP, Stevanato G, Sternkopf S, Moll D, Schroeder H, Becker S, Fischer A, Gerhardt E, Outeiro TF, Opazo F, Griesinger C, Glöggler S Journal Chemistry Methods Citation Chem. Methods 2022, e202200023. Abstract Nuclear magnetic resonance (NMR) is widely applied from analytics to

Authors Peña-Díaz S, Pujols J, Vasili E, Pinheiro F, Santos J, Manglano-Artuñedo Z, Outeiro TF, Ventura S Journal Journal of Biological Chemistry Citation J Biol Chem. 2022 Apr 4;298(5):101902. Abstract Parkinson’s disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as

Authors Farzadfard A, König A, Petersen SV, Nielsen J, Vasili E, Dominguez-Meijide A, Buell AK, Outeiro TF, Otzen DE Journal Journal of Biological Chemistry Citation J Biol Chem. 2022 Mar 18:101848. Abstract Glycation is a nonenzymatic posttranslational modification (PTM) known to be increased in the brains of hyperglycemic patients. Alpha-synuclein

Authors Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY Journal Science Reports Citation Sci Rep 12, 2987 (2022). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different

Authors Al-Azzani M, König A, Outeiro TF Journal Biomolecules Citation Biomolecules 2022, 12(2), 324. Abstract Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be associated