Outeiro, Tiago Fleming

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08.01.2024

Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma

Authors Quesnel A, Martin LD, Tarzi C, Lenis VP, Coles N, Islam M, Angione C, Outeiro TF, Khundakar AA, Filippou PS Journal Cancer Medicine Citation Cancer Med. 2024 Jan 8. Abstract Background Melanoma, the most lethal skin cancer type, occurs more frequently in Parkinson’s disease (PD), and PD is more
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19.10.2023

PrP meets alpha-synuclein: Molecular mechanisms and implications for disease

Authors Vieira TCRG, Barros CA, Domingues R, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2023 Oct 19. Abstract The discovery of prions has challenged dogmas and has revolutionized our understanding of protein-misfolding diseases. The concept of self-propagation via protein conformational changes, originally discovered for the prion protein (PrP),
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11.10.2023

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly
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30.08.2023

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease

Authors Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(17) Abstract Parkinson’s disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites
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18.08.2023

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Authors Sant’Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D Journal Molecular Medicine Citation Mol Med. 2023 Aug 18;29(1):111. Abstract Background: Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to
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09.08.2023

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice

Authors Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(16), 12607. Abstract Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without
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07.08.2023

Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis

Authors Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7:166835. Abstract Different SOD1 proteoforms are implicated## in both familial and sporadic cases of Amyotrophic Lateral Sclerosis
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01.08.2023

Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies

Authors Chopra A, Outeiro TF Journal Brain Citation Brain. 2023 Aug 1:awad260. Abstract Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‘Lewy bodies’ and ‘Lewy neurites’. Together with dementia with Lewy
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28.07.2023

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson’s disease

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a
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08.07.2023

More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy

Authors Flores-Leon M, Outeiro TF Journal Acta Neuropathologica Citation Acta Neuropathol. 2023 Jul 8. Abstract The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease (PD), and dementia with Lewy bodies (DLB). The main neuropathological hallmark of PD and
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