Mager, Thomas

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09.04.2024

Toward Optogenetic Hearing Restoration

Authors Huet A, Mager T, Goßler C, Moser T Journal Annual Review of Neurosciences Citation Annu Rev Neurosci. 2024 Apr 9. Abstract The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical
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28.01.2024

Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line

Authors Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2024 Jan 28;75:103317. Abstract Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal
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17.01.2024

CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K Journal BioRxiv Citation bioRxiv 2024.01.15.575777. Abstract Microbial rhodopsins are
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18.11.2023

Efficient and sustained optogenetic control of nervous and cardiac systems

Authors Zerche M, Hunniford V, Alekseev A, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Alvanos T, Witzke I, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T Journal BioRxiv Citation bioRxiv 2023.11.17.567544. Abstract Optogenetic control of cells is a
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21.03.2023

Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration

Authors Zerche M, Wrobel C, Kusch K, Moser T, Mager T Journal Molecular Therapy: Methods and Clinical Development Citation Molecular Therapy: Methods & Clinical Development Vol. 29 June 2023. Abstract Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically
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07.05.2021

Utility of red-light ultrafast optogenetic stimulation of the auditory pathway

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current
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08.10.2020

Viral rhodopsins 1 are an unique family of light-gated cation channels

Authors Zabelskii D, Alekseev A, Kovalev K, Rankovic V, Balandin T, Soloviov D, Bratanov D, Savelyeva E, Podolyak E, Volkov D, Vaganova D, Astashkin R, Chizhov I, Yutin N, Rulev M, Popov A, Eria-Oliveira AS, Rokitskaya T, Mager T, Antonenko Y, Rosselli R, Armeev G, Shaitan K, Vivaudou M, Büldt
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