Jakobs, Stefan

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.

Authors Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz C, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Urlaub H, Rehling P Journal Nature Communications Citation Nat Commun 12, 5715 (2021) Abstract Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported

Authors Siegmund R, Werner F, Jakobs S, Geisler C, Egner A Journal Biophysical Journal Citation Biophys J. 2021 Jul 8:S0006-3495(21)00556-7. Abstract Fluorescence microscopy is an excellent tool to gain knowledge on cellular structures and biochemical processes. Stimulated emission depletion (STED) microscopy provides a resolution in the range of a few

Authors Tameling C, Stoldt S, Stephan T, Naas J, Jakobs S, Munk A Journal Nature Computational Science Citation Nat Comput Sci 1, 199–211 (2021). Abstract Super-resolution fluorescence microscopy is a widely used technique in cell biology. Stimulated emission depletion (STED) microscopy enables the recording of multiple-color images with subdiffraction resolution.

Authors Weber M, Leutenegger M, Stoldt S, Jakobs S, Mihaila TS, Butkevich AN, Hell SW Journal Nature Photonics Citation Nat. Photonics 15, 361–366 (2021). Abstract We introduce MINSTED, a fluorophore localization and super-resolution microscopy concept based on stimulated emission depletion (STED) that provides spatial precision and resolution down to the

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore

Authors Pape JK, Stephan T, Balzarotti F, Büchner R, Lange F, Riedel D, Jakobs S, Hell SW Journal Proceedings of the National Academy of Sciences Citation PNAS, Aug 2020, 202009364. Abstract The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the

Authors Stephan T, Bruser C, Deckers M, Steyer M, Balzarotti F, Barbot M, Behr TS, Heim G, Hubner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S Journal EMBO Journal Citation EMBO J 2020 Jun 22;e104105

Authors Jakobs S, Stephan T, Ilgen P, Brüser C Journal Annual Reviews of Biophysics Citation Annu Rev Biophys. 2020 May 6;49:289-308. Abstract Mitochondria are essential for eukaryotic life. These double-membrane organelles often form highly dynamic tubular networks interacting with many cellular structures. Their highly convoluted contiguous inner membrane compartmentalizes the