Jakobs, Stefan

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10.10.2024

Direct optical measuerement of intramolecular distances with angstrom precision

Authors Sahl SJ, Matthias J, Inamdar K, Weber M, Khan TA, Brüser C, Jakobs S, Becker S, Griesinger C, Broichhagen J, Hell SW Journal Science Citation Science. 2024 Oct 11;386(6718):180-187. Abstract Optical investigations of nanometer distances between proteins, their subunits, or other biomolecules have been the exclusive prerogative of Förster
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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13.09.2024

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Authors Naas J, Nies G, Li H, Stoldt S, Schmitzer B, Jakobs S, Munk A Journal Communications Biology Citation Commun Biol 7, 1139 (2024). Abstract With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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27.05.2024

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Authors Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A Journal Cells Citation Cells. 2024 May 27;13(11):923. Abstract Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic
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30.04.2024

An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells

Authors Chen J, Stephan T, Gaedke F, Liu T, Li Y, Schauss A, Chen P, Wulff V, Jakobs S, Jüngst C, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2317703121. Abstract Fluorescence
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04.04.2024

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

Authors Oleksiievets N, Mougios N, Jans DC, Hauke L, Thiele JC, Basak S, Jakobs S, Opazo F, Enderlein J, Tsukanov R, Sananbenesi F, Fischer A   Journal BioRxiv   Citation bioRxiv 2024.04.02.587536.   Abstract DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) is a potent variant of single-molecule localization microscopy
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15.02.2024

In-situ architecture of the human prohibitin complex

Authors Lange F, Ratz M, Dohrke JN, Wenzel D, Ilgen P, Riedel D, Jakobs S Journal BioRxiv Citation bioRxiv 2024.02.14.579514. Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation
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22.01.2024

Drosophila MIC10b can polymerize into cristae-shaping filaments

Authors Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S Journal Life Science Alliance Citation Life Sci Alliance. 2024 Jan 22;7(4):e202302177. Abstract Cristae are invaginations of the mitochondrial inner membrane
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08.12.2023

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

Authors Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C Journal iScience Citation iScience. 2023 Dec 8;27(1):108700. Abstract Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand
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