Hillen, Hauke

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22.05.2024

The molecular machinery for maturation of primary mtDNA transcripts

Authors Vučković A, Freyer C, Wredenberg A, Hillen HS Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R19-R25. Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs). Mitochondrial transcription produces long, polycistronic transcripts that
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04.04.2024

Molecular basis of human nuclear and mitochondrial tRNA 3′-processing

Authors Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen H Journal BioRxiv Citation bioRxiv 2024.04.04.588063. Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3’-end processing of both nucleus-encoded (nu-tRNAs) and mitochondria-encoded tRNAs (mt-tRNAs). ELAC2
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29.02.2024

Structure of the multi-subunit chloroplast RNA polymerase

Authors do Prado PFV, Ahrens FM, Liebers M, Ditz N, Braun HP, Pfannschmidt T, Hillen HS   Journal Molecular Cell   Citation Mol Cell (2024) 84, 1–16.   Abstract Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by
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29.12.2023

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although
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22.10.2022

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Authors Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA Journal Cellular and Molecular Life Sciences Citation Cell Mol Life Sci. 2022 Oct 22;79(11):562. Abstract Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms
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05.07.2022

WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly

Authors Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li
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18.06.2022

Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes

Authors Bhatta A, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Jun 18:S0968-0004(22)00139-6. Abstract Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.
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08.10.2021

Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis

Authors Lavdovskaia E, Hillen HS, Richter-Dennerlein R Journal Trends in Cell Biology Citation Trends Cell Biol. 2021. Abstract Final maturation steps during ribo-some biogenesis require the assis-tance of assembly and qualitycontrol factors to ensure the foldingof rRNA and proteins into a func-tional translation machinery. Herewe integrate several recent struc-tural snapshots
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06.09.2021

Structural basis of RNA processing by human mitochondrial RNase P

Authors Bhatta A, Dienemann C, Cramer P, Hillen HS Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol (2021). Abstract Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species.
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24.08.2021

The structure of a dimeric form of SARS-CoV-2 polymerase

Authors Jochheim FA, Tegunov D, Hillen HS, Schmitzova J, Kokic G, Dienemann C, Cramer P Journal Communications Biology Citation Commun Biol. 2021 Aug 24;4(1):999. Abstract The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed
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