Hillen, Hauke

Home >> Publications >> Author >> Hillen, Hauke
Feature image not available
29.12.2023

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although
Learn More
Feature image not available
22.10.2022

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Authors Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA Journal Cellular and Molecular Life Sciences Citation Cell Mol Life Sci. 2022 Oct 22;79(11):562. Abstract Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms
Learn More
Feature image not available
05.07.2022

WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly

Authors Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li
Learn More
Feature image not available
18.06.2022

Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes

Authors Bhatta A, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Jun 18:S0968-0004(22)00139-6. Abstract Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.
Learn More
Feature image not available
08.10.2021

Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis

Authors Lavdovskaia E, Hillen HS, Richter-Dennerlein R Journal Trends in Cell Biology Citation Trends Cell Biol. 2021. Abstract Final maturation steps during ribo-some biogenesis require the assis-tance of assembly and qualitycontrol factors to ensure the foldingof rRNA and proteins into a func-tional translation machinery. Herewe integrate several recent struc-tural snapshots
Learn More
Feature image not available
06.09.2021

Structural basis of RNA processing by human mitochondrial RNase P

Authors Bhatta A, Dienemann C, Cramer P, Hillen HS Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol (2021). Abstract Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species.
Learn More
Feature image not available
24.08.2021

The structure of a dimeric form of SARS-CoV-2 polymerase

Authors Jochheim FA, Tegunov D, Hillen HS, Schmitzova J, Kokic G, Dienemann C, Cramer P Journal Communications Biology Citation Commun Biol. 2021 Aug 24;4(1):999. Abstract The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed
Learn More
Feature image not available
11.08.2021

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Authors Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2021). 2021 Aug 11. Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of
Learn More
Feature image not available
16.06.2021

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Authors Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2021 Jun 16;12(1):3672. Abstract Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC)
Learn More
Feature image not available
06.04.2021

Structure and function of SARS-CoV-2 polymerase

Authors Hillen HS Journal Current Opinion in Virology Citation Current Opinion in Virology 2021, 48:82–90. Abstract Coronaviruses use an RNA-dependent RNA polymerase (RdRp) to replicate and express their genome. The RdRp associates with additional non-structural proteins (nsps) to form a replication-transcription complex (RTC) that carries out RNA synthesis, capping and
Learn More
X
EN DE
X
X