Cyganek, Lukas

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15.09.2022

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

Authors Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N, Voigt N. Journal Communications Biology Citation Commun Biol 2022 Sep 15;5(1):969. Abstract Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer from low-throughput and require considerable experimenter expertise. Automated
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18.08.2022

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming

Authors Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW Journal Star Protocols Citation STAR Protoc. 2022 Aug 18;3(3):101560. Abstract The methods for the culture and cardiomyocyte differentiation of human embryonic stem cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex and
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10.01.2022

Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells

Authors Pavez-Giani MG, Cyganek L Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Jan 10;9:800529. Abstract Around one third of patients with mitochondrial disorders develop a kind of cardiomyopathy. In these cases, severity is quite variable ranging from asymptomatic status to severe manifestations including heart
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22.12.2021

Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis

Authors Barbarics B, Eildermann K, Kaderali L, Cyganek L, Plessmann U, Bodemeyer J, Paul T, Ströbel P, Urlaub H, Tirilomis T, Lenz C, Bohnenberger H. Journal Scientific Reports Citation Sci Rep. 2021 Dec 22;11(1):24389. Abstract Aortic valve stenosis (AVS) is one of the most common valve diseases in the world.
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