Alves, Frauke

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22.01.2025

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Authors Frohn J, Böddeker F, Reichardt M, Bruns H, Czajka T, Khan A, Broche L, Krisch M, Bravin A, Alves F, Zschüntzsch J, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Jan 22;15(1):2766. Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is
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23.09.2024

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Authors Bharti A, Ajinkya K, Andrea MM, Ramos-Gomes F, Bohnenberger H, Ströbel P, Alves F, Klein O Journal npj Imaging Citation npj Imaging 2, 35 (2024). Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, accentuated by its heterogeneity and complex tumour microenvironment (TME). The role of
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13.06.2024

Autonomous bioluminescence emission from transgenic mice

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal BioRxiv Citation bioRxiv 2024.06.13.598801. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here
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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on
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08.01.2024

Characterization of transient and progressive pulmonary fibrosis by spatially correlated phase contrast microCT, classical histopathology and atomic force microscopy

Authors D’Amico L, Svetlove A, Longo E, Meyer R, Senigagliesi B, Saccomano G, Nolte P, Wagner WL, Wielpütz MO, Leitz DHW, Duerr J, Mall MA, Casalis L, Köster S, Alves F, Tromba G, Dullin C Journal Computers in Biology and Medicine Citation Comput Biol Med. 2024 Jan 8;169:107947. Abstract Pulmonary
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02.10.2023

X-ray phase contrast 3D virtual histology characterises complex tissue architecture in colorectal cancer

Authors Svetlove A, Griebel T, Albers J, D’Amico L, Nolte P, Tromba G, Bohnenberger H, Alves F, Dullin C Journal Frontiers in Gastroenterology Citation Front. Gastroenterol.Sec. Gastroenterology and Cancer. Volume 2 – 2023 Abstract Precise morphological analysis of tumour tissue samples is crucial for accurate diagnosis and staging of colorectal
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10.07.2023

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging

Authors Markus MA, Ferrari DP, Alves F, Ramos-Gomes F Journal Biomedical Optics Express Citation Biomed. Opt. Express 14, 3988-4002 (2023). Abstract Fixation methods such as formalin are commonly used for the preservation of tissue with the aim of keeping their structure as close as possible to the native condition. However,
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02.05.2023

Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis

Authors Pinkert-Leetsch D, Frohn J, Ströbel P, Alves F, Salditt T, Missbach-Guentner J Journal Cancer Imaging Citation Cancer Imaging. 2023 May 2;23(1):43. Abstract Background: The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which still has one of the lowest survival rates, requires novel imaging tools to improve early detection and
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12.04.2023

Monitoring the response to Nintedanib treatment in a mouse model of lung fibrosis using longitudinal X-ray based lung function measurement

Authors Khan A, Markus AM, Svetlove A, Hülsmann S, Alves F, Dullin C Journal Research Square Citation Research Square, 12 April 2023, preprint. Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive, incurable, and debilitating fibrotic disease. Nintedanib – an oral tyrosine kinase inhibitor – significantly slows the IPF
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08.09.2022

The murine male reproductive organ at a glance: Three-dimensional insights and virtual histology using label-free light sheet microcopy

Authors Pinkert-Leetsch D, Rost JU, Schmiedeknecht MUH, Stadelmann C, Alves F, Missbach-Guentner J Journal Andrology Citation Andrology. 2022 Sep 8. Abstract Background: The unique anatomy of the male reproductive organ reflects its complex function from sperm maturation to their storage for months until emission. Since light microscopy in two dimensions
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