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10.03.2026

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Mohseni F, Vukušić K, Tirincsi A, Wardenaar R, Losito M, Harmsen I, Gönenc II, Wollnik B, Foijer F, Tolić IM, Storchová Z, Räschle M Journal Nucleid Acid Research Citation Nucleic Acids Res. 2026 Feb 24;54(5):gkag199. Abstract The BLM helicase is a critical genome maintenance protein
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10.03.2026

Visualizing the multidimensional landscape of biological variation in modern microscopy

Authors Müller GF, Göpel T, Scherf N, Huisken J. Journal Frontiers in Bioinformatics Citation Front Bioinform. 2026 Mar 10;6:1757489. Abstract Variation is a foundational biological principle that has historically been marginalized-both due to limited experimental accessibility and because of idealized, stereotypic blueprints rooted in essentialist thinking. With the advent of
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09.03.2026

Arousal elicits a brain-wide hemodynamic wave independent of locus coeruleus noradrenergic tone

Authors Martinez de Paz JM, Mayer JL, Wanken P, Rodrigues Apgaua B, Ablitip A, Behera L, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.710089. Abstract Arousal fluctuations during wakefulness have a major impact on physiology and behavior, including perception and task performance. Arousal is also known to be a strong modulator
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09.03.2026

Image modifications reduce differences in natural-image encoding by retinal ganglion cells between natural and optogenetic stimulation

Authors Ramakrishna V, Gollisch T Journal BioRxiv Citation bioRxiv 2026.03.06.710066. Abstract Photoreceptor degeneration is among the leading causes of blindness and optogenetics as a potential therapeutic measure has garnered much attention over recent years. In this approach, light-sensitive molecules like Channelrhodopsin-2 (ChR2) are inserted into neurons in the retina to
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06.03.2026

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

Authors Ehses K, López-Alonso JP, Antico O, Azem A, Muqit MMK, Ubarretxena-Belandia I, Fernández-Busnadiego R Journal Science Advances Citation Sci Adv. 2026. Sci Adv. 2026 Mar 6;12(10):eaed3579. Abstract Cells have evolved organelle-specific responses to maintain protein homeostasis (proteostasis). During proteostatic stress, mitochondria down-regulate translation and enhance protein folding, yet the
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06.03.2026

A transition-prone brain state precedes spontaneous behavioral switching

Authors Wanken P, Edelman BJ, Behera L, Martinez de Paz JM, McCarthy PT, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.709845. Abstract Animals exhibit behavior in the absence of external stimuli or explicit tasks. Is the initiation of such spontaneous behavior shaped by internal brain states in a predictable manner? If
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Heart muscle cells cultivated in the laboratory from iPS cells: The image shows the structure of the muscle fibres. The project at Göttingen University Medical Centre (UMG), funded by the zukunft.niedersachsen programme, works with such patient-specific models. Image: umg/lukas cyganek

03.03.2026

Precision medicine for rare heart diseases

Göttingen research receives millions in funding   The University Medical Center Göttingen (UMG) is receiving over one million euros from the zukunft.niedersachsen funding programme for a gene therapy project to treat Noonan syndrome. The focus is on developing individually tailored therapies for children with heart disease.   Rare diseases often
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Super-resolution image of cytoskeleton and focal adhesion proteins taken using the new versatile and cost-effective microfluidics system. The “overlay” of all the different target molecules reveals exquisite and complex detail up to 100 times sharper than conventional microscopy. Photo: adapted from the original publication in ACS Nano (2026). DoI: 10.1021/acsnano.5c18697

03.03.2026

Tiny flows, big insights: microfluidics system boosts super-resolution microscopy

International research team led by Göttingen University design versatile imaging system   Understanding how cells are organized and how their molecular components interact in a coordinated and cooperative manner is a central goal of modern life sciences. To answer these questions, researchers need to observe many structures inside the same
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03.03.2026

Mechanism of human tRNA 3′CCA maturation

Authors Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen H Journal BioRxiv Citation bioRxiv 2026.03.02.709036. Abstract The non-templated addition of the 3′CCA end is the final universal step of tRNA maturation. In humans, 3′CCA addition on nuclear- (nu-tRNA) and mitochondria-encoded tRNAs (mt-tRNA) is catalyzed by a single
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