2024 – Page 19

03.04.2024

Young Scientist Award for Viola Priesemann

During this year’s spring conference of the German Physical Society (DPG), MBExC member Viola Priesemann received the Young Scientist Award for Socio- and Econophysics. The physicist conducts research at the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) and the University of Göttingen. The prize is endowed with 7,500 euros

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03.04.2024

1.5 million to study diseased cardiac muscle

An Europe-wide initiative of the British Heart Foundation (BHF), the German Centre for Cardiovascular Research (DZHK) and the Dutch Heart Foundation (DHF) is funding four projects with a cardiovascular research focus in order to achieve new approaches in the diagnosis and treatment of cardiovascular diseases. The “Shift-DCM” project led by

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03.04.2024

Structural basis of Integrator-dependent RNA polymerase II termination

Authors Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P Journal Nature Citation Nature. 2024 Apr 3. Abstract The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator

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03.04.2024

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

Authors López-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320505121. Abstract The presynaptic

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01.04.2024

Heart & Brain – understanding together

New special exhibition at the Forum Wissen opens on 18 April 2024 How does a “patch” for the heart work? Can we hear with light? And how can insights from basic research be used to help diagnose and treat diseases? The “Heart & Brain – understanding together” exhibition examines

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29.03.2024

Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation

Authors Maurer W, Rebs S, Köhne S, Eberl H, Wollnik B, Zibat A, Streckfuss-Bömeke K Journal Stem Cell Research Citation Stem Cell Res. 2024 Mar 29;77:103409. Abstract Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to

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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on

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27.03.2024

Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding

Authors Zhang C, Revah O, Wolf F, Neef A Journal Journal of Neuroscience Citation J Neurosci. 2024 Mar 27;44(13):e0799232023. Abstract Modern, high-density neuronal recordings reveal at ever higher precision how information is represented by neural populations. Still, we lack the tools to understand these processes bottom-up, emerging from the biophysical

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27.03.2024

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments

Authors Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. Abstract Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably,

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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J Journal Nature Citation Nature. 2024 Apr;628(8006):145-153. Abstract As hippocampal neurons respond to diverse types

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