2024

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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J   Journal Nature   Citation Nature. 2024 Apr;628(8006):145-153.   Abstract As hippocampal neurons respond to diverse types
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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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22.03.2024

Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures

Authors Shvachiy L, Amaro-Leal Â, Machado F, Rocha I, Outeiro TF, Geraldes V Journal Biomedicines Citation Biomedicines. 2024 Mar 22;12(4):711. Abstract Lead exposure is a significant health concern, ranking among the top 10 most harmful substances for humans. There are no safe levels of lead exposure, and it affects multiple
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20.03.2024

[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brain

Authors Saw RS, Buss S, Schmidt F, Ryazanov S, Leonov A, Kuebler L, Bleher D, Papadopoulos I, Roeben B, Schmidt F, Reimold M, Bonanno F, Grotegerd AK, Ruf V, Dahl B, Sandiego C, Henry K, Fehrenbacher B, Schaller M, Kahle P, Gasser T, Brockmann K, Reischl G, la Fougère C,
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20.03.2024

METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

Authors Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y   Journal Cell Death & Disease   Citation Cell Death Dis 15, 229 (2024).   Abstract Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging
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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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19.03.2024

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Authors Morici M, Gabrielli S, Fujiwara K, Paternoga H, Beckert B, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2432.   Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to
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