2024

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19.03.2024

Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose

Authors Lamtar Mohammadi EL, Keikha R, Outeiro TF, Jebali A   Journal Cellulose   Citation Cellulose (2024)   Abstract Interfering with the aggregation of the protein alpha-synuclein (aSyn) has been a topic of research for > 25 years, as this protein is found in pathognomonic protein aggregates in the brain of
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Preparing the heart patch for the surgery. Photo: UKSH

18.03.2024

Two years with heart patch: patient reports on experiences

Unique in the world: laboratory-grown heart tissue has been implanted in patients with heart failure as part of a study conducted by the University Medical Center Göttingen (UMG) and the University Hospital Schleswig-Holstein (UKSH). The so-called heart patch is intended to strengthen the heart permanently and has the potential for
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17.03.2024

Multiscale Quantile Regression with Local Error Control

Authors Liu Z, Li H   Journal Arxiv   Citation arXiv:2403.11356.   Abstract For robust and efficient detection of change points, we introduce a novel methodology MUSCLE (multiscale quantile segmentation controlling local error) that partitions serial data into multiple segments, each sharing a common quantile. It leverages multiple tests for
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15.03.2024

Protocol to develop force-generating human skeletal muscle organoids

Authors Shahriyari M, Rinn M, Hofemeier AD, Babych A, Zimmermann WH, Tiburcy M Journal Star Protocols Citation STAR Protoc. 2024 Mar 15;5(1):102794. Abstract Force generation is an essential property of skeletal muscle models in vitro. We describe a versatile 1-step procedure to direct undifferentiated human pluripotent stem cells (PSCs) into
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MBExC special exhibition "Heart & Brain - Understanding Together" at Forum Wissen

13.03.2024

Heart & Brain – Understanding Together

New special exhibition at the Forum Wissen opens on 18 April 2024   How does a “patch” for the heart work? Can we hear with light? And how can insights from basic research be used to help diagnose and treat diseases? The “Heart & Brain – understanding together” exhibition examines
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13.03.2024

Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications

Authors Chelban V, Aksnes H, Maroofian R, LaMonica LC, Seabra L, Siggervåg A, Devic P, Shamseldin HE, Vandrovcova J, Murphy D, Richard AC, Quenez O, Bonnevalle A, Zanetti MN, Kaiyrzhanov R, Salpietro V, Efthymiou S, Schottlaender LV, Morsy H, Scardamaglia A, Tariq A, Pagnamenta AT, Pennavaria A, Krogstad LS, Bekkelund
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12.03.2024

mtDNA analysis using Mitopore

Authors Dobner J, Nguyen T, Pavez-Giani MG, Cyganek L, Distelmaier F, Krutmann J, Prigione A, Rossi A Journal Molecular Therapy: Methods & Clinical Development Citation Mol Ther Methods Clin Dev. 2024 Mar 12;32(2):101231. Abstract Mitochondrial DNA (mtDNA) analysis is crucial for the diagnosis of mitochondrial disorders, forensic investigations, and basic
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11.03.2024

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3′-UTR and promoting Rag1 mRNA expression

Authors Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer
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10.03.2024

3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes

Authors Pochechueva TV, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, Lehnart SE Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2024 Mar 10;25(6):3183. Abstract We present novel workflows for Q-FISH nanoscopy with the potential for prognostic applications and resolving novel chromatin compaction changes. DNA-fluorescence
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09.03.2024

Convolutional neural network models of the primate retina reveal adaptation to natural stimulus statistics

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2024.03.06.583740. Abstract The diverse nature of visual environments demands that the retina, the first stage of the visual system, encodes a vast range of stimuli with various statistics. The retina adapts its computations to some
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