2024

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15.04.2024

Click Chemistry with Cell-Permeable Fluorophores Expands the Choice of Bioorthogonal Markers for Two-Color Live-Cell STED Nanoscopy

Authors Gregor C, Grimm F, Rehman J, Wurm CA, Egner A Journal Cells Citation Cells 2024, 13(8), 683. Abstract STED nanoscopy allows for the direct observation of dynamic processes in living cells and tissues with diffraction-unlimited resolution. Although fluorescent proteins can be used for STED imaging, these labels are often
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13.04.2024

α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway

Authors Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA Journal Cell Death & Disease Citation Cell Death Dis. 2024 Apr 13;15(4):264. Abstract Cognitive dysfunction and dementia
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10.04.2024

A subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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10.04.2024

How Natural Enzymes and Synthetic Ribozymes Generate Methylated Nucleotides in RNA

Authors Höbartner C, Bohnsack KE, Bohnsack MT Journal Annual Review of Biochemistry Citation Annu Rev Biochem. 2024 Apr 10. Abstract Methylation of RNA nucleotides represents an important layer of gene expression regulation, and perturbation of the RNA methylome is associated with pathophysiology. In cells, RNA methylations are installed by RNA
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10.04.2024

A novel subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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09.04.2024

Toward Optogenetic Hearing Restoration

Authors Huet A, Mager T, Goßler C, Moser T Journal Annual Review of Neurosciences Citation Annu Rev Neurosci. 2024 Apr 9. Abstract The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical
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04.04.2024

Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice

Authors Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P; MDS Journal Movement Disorders Citation Mov Disord. 2024 Apr 4. Abstract Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here,
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04.04.2024

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

Authors Oleksiievets N, Mougios N, Jans DC, Hauke L, Thiele JC, Basak S, Jakobs S, Opazo F, Enderlein J, Tsukanov R, Sananbenesi F, Fischer A   Journal BioRxiv   Citation bioRxiv 2024.04.02.587536.   Abstract DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) is a potent variant of single-molecule localization microscopy
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Prof. Dr. Viola Priesemann. Photo: MPI-DS / Peter Heller

03.04.2024

Young Scientist Award for Viola Priesemann

During this year’s spring conference of the German Physical Society (DPG), MBExC member Viola Priesemann received the Young Scientist Award for Socio- and Econophysics. The physicist conducts research at the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) and the University of Göttingen. The prize is endowed with 7,500 euros
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Dr. Lukas Cyganek, Department of Cardiology and Pneumology, Head of the Stem Cell Unit, University Medical Center Göttingen. Photo: umg/hzg

03.04.2024

1.5 million to study diseased cardiac muscle

An Europe-wide initiative of the British Heart Foundation (BHF), the German Centre for Cardiovascular Research (DZHK) and the Dutch Heart Foundation (DHF) is funding four projects with a cardiovascular research focus in order to achieve new approaches in the diagnosis and treatment of cardiovascular diseases. The “Shift-DCM” project led by
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