2024

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24.04.2024

Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy

Authors Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A Journal Biological Chemistry Citation Biol Chem. 2024 Apr 24. Abstract Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here,
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The safety and benefits of optical cochlear implants are investigated on marmosets before they are tested on humans. Source: Anton Säckl

23.04.2024

Talking about animal testing

Adressing an emotional topic with transparency and facts   Animal experiments in research is a topic that is often less about facts and more about emotionally charged opinions. This is also due to the fact that scientists are often reluctant to comment on the subject, if at all. The scientific
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21.04.2024

Myosin II actively regulates Drosophila proprioceptors

Authors Guan C, Nishi K, Kreis CT, Baeumchen O, Goepfert MC, Schmidt CF Journal BioRxiv Citation bioRxiv 2024.04.18.590050. Abstract Auditory receptors can be motile to actively amplify their mechanical input. Here we describe a novel and different type of motility that, residing in supporting cells, shapes physiological responses of mechanoreceptor
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18.04.2024

Microtubules: highway to … arrhythmia?

Authors Liutkute A, Prosser BL, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2024 Apr 18:cvae072. Abstract No abstract available DOI 10.1093/cvr/cvae072   Pubmed Link
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18.04.2024

Cerebellar Ex Vivo Magnetic Resonance Imaging at its Feasibility Limit: Up to 77-Microns Isotropic Resolution using Low-Bandwidth Balanced Steady State Free Precession (LoBa-bSSFP) Sequences and 3T Standard Equipment

Authors Weigel M, Dechent P, Galbusera R, Bahn E, Lu PJ, Kappos L, Brueck W, Stadelmann C, Granziera C Journal BioRxiv Citation bioRxiv 2024.04.18.589707. Abstract Background: Ultra-high-resolution magnetic resonance imaging of the ex vivo brain is increasingly becoming an indispensable tool for studying the morphology and potential pathology of the
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Gerd Hasenfuß received DGIM Leopold Lichtwitz Medal 2024.

16.04.2024

Gerd Hasenfuß received Leopold Lichtwitz Medal

Professor Gerd Hasenfuß received the Leopold Lichtwitz Medal of the German Society of Internal Medicine (DGIM) at the annual congress in recognition of his great services to internal medicine. Hasenfuß has been Director of the Clinic for Cardiology and Pneumology since 1998, University Professor of Internal Medicine at the University
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15.04.2024

Click Chemistry with Cell-Permeable Fluorophores Expands the Choice of Bioorthogonal Markers for Two-Color Live-Cell STED Nanoscopy

Authors Gregor C, Grimm F, Rehman J, Wurm CA, Egner A Journal Cells Citation Cells 2024, 13(8), 683. Abstract STED nanoscopy allows for the direct observation of dynamic processes in living cells and tissues with diffraction-unlimited resolution. Although fluorescent proteins can be used for STED imaging, these labels are often
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13.04.2024

α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway

Authors Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA Journal Cell Death & Disease Citation Cell Death Dis. 2024 Apr 13;15(4):264. Abstract Cognitive dysfunction and dementia
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10.04.2024

A subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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10.04.2024

How Natural Enzymes and Synthetic Ribozymes Generate Methylated Nucleotides in RNA

Authors Höbartner C, Bohnsack KE, Bohnsack MT Journal Annual Review of Biochemistry Citation Annu Rev Biochem. 2024 Apr 10. Abstract Methylation of RNA nucleotides represents an important layer of gene expression regulation, and perturbation of the RNA methylome is associated with pathophysiology. In cells, RNA methylations are installed by RNA
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