2024

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24.08.2024

TOM-TIM23 supercomplex formation

Authors Jain N, Gomkale R, Rehling P Journal Methods in Enzymology Citation Methods Enzymol. 2024;707:3-22. Abstract Mitochondria import the vast majority of proteins from the cytosol. Protein translocation machineries in outer and inner membranes facilitate precursor recognition and transport. Most mitochondrial proteins utilize N-terminal presequences as targeting signals that eventually
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22.08.2024

Optical control of pH via chromoselective photodosimetry

Authors Chaudhuri A, Eijsink LE, Simeth NA Journal Chemical Communications (Cambridge) Citation Chem Commun (Camb). 2024 Aug 22. Abstract The dynamic regulation of pH via an external stimulus is an attractive technique to gate chemical transformations. Applying photons of different energy, we preferentially address either a photoacid or a photobase
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Illustration of the protein folding helper complexes in bullet shape (blue) and football shape (red) in their natural environment surrounded by a variety of different proteins. Foreground: High-resolution structure of the protein folding helper complex in cross-section. A protein to be folded is visible inside (yellow). Illustration: Jonathan Wagner, MPI of Biochemistry

22.08.2024

Protein folding helpers in their natural environment

Scientists from Martinsried and Göttingen have analyzed protein folding helpers, so-called chaperonin complexes, in their natural environment using cryo-electron tomography.   Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in
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22.08.2024

Signatures of hierarchical temporal processing in the mouse visual system

Authors Rudelt L, González Marx D, Spitzner FP, Cramer B, Zierenberg J, Priesemann V. Journal PLoS Computational Biology Citation PLoS Comput Biol. 2024 Aug 22;20(8):e1012355. Abstract A core challenge for the brain is to process information across various timescales. This could be achieved by a hierarchical organization of temporal processing
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22.08.2024

Empirical Optimal Transport under Estimated Costs: Distributional Limits and Statistical Applications

Authors Hundrieser S, Mordant G. Weitkamp CA, Munk A Journal Stochastic Processes and their Applications Citation Stochastic Processes and their Applications 178 (2024) 104462. Abstract Optimal transport (OT) based data analysis is often faced with the issue that the underlying cost function is (partially) unknown. This is addressed in this
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Illustration of the protein folding helper complexes in bullet shape (blue) and football shape (red) in their natural environment surrounded by a variety of different proteins. Foreground: High-resolution structure of the protein folding helper complex in cross-section. A protein to be folded is visible inside (yellow). Illustration: Jonathan Wagner, MPI of Biochemistry

21.08.2024

Protein folding helpers in their natural environment

Scientists from Martinsried and Göttingen have analyzed protein folding helpers, so-called chaperonin complexes, in their natural environment using cryo-electron tomography.   Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in
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21.08.2024

Visualizing chaperonin function in situ by cryo-electron tomography

Authors Wagner J, Carvajal AI, Bracher A, Beck F, Wan W, Bohn S, Körner R, Baumeister W, Fernandez-Busnadiego R, Hartl FU Journal Nature Citation Nature. 2024 Aug 21. Abstract Chaperonins are large barrel-shaped complexes that mediate ATP-dependent protein folding1-3. The bacterial chaperonin GroEL forms juxtaposed rings that bind unfolded protein
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20.08.2024

Variational calculus approach to Zernike polynomials with application to fluorescence correlation spectroscopy

Authors Gligonov I, Enderlein J Journal Biophysical Journal Citation Biophys J. 2024 Aug 19:S0006-3495(24)00557-5. Abstract Zernike polynomials are a sequence of orthogonal polynomials that play a crucial role in optics and, in particular, modeling microscopy systems. Introduced by Frits Zernike in 1934, they are particularly useful in expressing wavefront aberrations
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20.08.2024

Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

Authors Zapp SJ, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Krueppel S, Mietsch M, Protti DA, Karamanlis D, Gollisch T Journal eLife Citation eLife13:RP99945. Abstract A standard circuit motif in sensory systems is the pooling of sensory information from an upstream neuronal layer. A downstream neuron thereby collects signals
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