2024

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12.08.2024

Morphological correlates of synaptic protein turnover in the mouse brain

Authors Li F, Bahr JN, Bierth FA, Reshetniak S, Tetzlaff C, Fornasiero EF, Wichmann C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2024 Aug 12;7(11):e202402793. Abstract Synaptic proteins need to be replaced regularly, to maintain function and to prevent damage. It is unclear whether this process, known
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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11.08.2024

Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase

Authors Rotsch AH, Li D, Dupont M, Krischuns T, Oberthuer C, Stelfox A, Lukarska M, Fianu I, Lidschreiber M, Naffakh N, Dienemann C, Cusack S, Cramer P Journal BioRxiv Citation bioRxiv 2024.08.11.607481. Abstract Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′
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07.08.2024

Visible and near-infrared light-induced photoclick reactions

Authors Fu Y, Simeth NA, Szymanski W, Feringa BL Journal Nature Reviews Chemistry Citation Nat Rev Chem. 2024 Aug 7. Abstract Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer
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06.08.2024

A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies

Authors Amaral L, Mendes F, Côrte-Real M, Rego A, Outeiro TF, Chaves SR Journal Chemosphere Citation Chemosphere. 2024 Aug 6:143039. Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein
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05.08.2024

Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation

Authors Kim R, Nagel SH, Liaw NY, Zimmermann WH, Zelarayan LC, Schoger E Journal Stem Cell Research Citation Stem Cell Research (2024). Abstract The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived
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Representation of the highly sensitive detector that is part of the newly developed fluorescence microscope. It consists of 23 individual detectors, enabling the resolution to be doubled. Photo: Alexey Chizhik, Göttingen University

02.08.2024

Glimpse into the nanoworld: microscope reveals tiniest cell processes

Research team including Göttingen University develops high-resolution fluorescence microscope   What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers from the Universities of Göttingen and Oxford, in collaboration with the University Medical
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02.08.2024

Doubling the resolution of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy

Authors Radmacher N, Nevskyi O, Gallea JI, Thiele JC, Gregor I, Rizzoli SO, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2024). Abstract In this study, we integrate a single-photon detector array into a confocal laser scanning microscope, enabling the combination of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy.
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01.08.2024

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

Authors Amedei H, Paul NB, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation Front. Anal. Sci. 4:1425190. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de
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A view into the cell using an optical laser trap: it localizes microscopic particles in order to draw conclusions about their random trembling movement. A new approach developed by the Göttingen researchers makes it possible to deduce from these movements how hard, soft or liquid the inside of the cell is. Photo: Till Moritz Münker

31.07.2024

“Laser view” into the avocado: new method reveals cell interior

Research team at the University of Göttingen develops method for recognizing cell properties   Checking whether an avocado is hard or soft by looking at it? This would require recognizing how the plant cells behave behind the skin. The same applies to all other cells on our planet: Despite more
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