2023

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27.03.2023

Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation

Authors Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF Journal Chemistry – A European Journal Citation Chem. Eur. J.2023, e202300649. Abstract Alpha-Synuclein (α-Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleino-pathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of
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27.03.2023

Discrimination between cyclic-nucleotides by cyclic-nucleotide gated ion channels

Authors Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S   Journal Nature Structural and Molecular Biology   Citation Nat Struct Mol Biol. 2023 Mar 27.   Abstract Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the
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21.03.2023

Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration

Authors Zerche M, Wrobel C, Kusch K, Moser T, Mager T Journal Molecular Therapy: Methods and Clinical Development Citation Molecular Therapy: Methods & Clinical Development Vol. 29 June 2023. Abstract Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically
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20.03.2023

A quantitative fluorescence-based approach to study mitochondrial protein import

Authors Jain N, Gomkale R, Bernhard O, Rehling P, Cruz-Zaragoza LD Journal EMBO Reports Citation EMBO Rep. 2023 Mar 20:e55760. Abstract Mitochondria play central roles in cellular energy production and metabolism. Most proteins required to carry out these functions are synthesized in the cytosol and imported into mitochondria. A growing
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15.03.2023

Defective COX1 expression in aging mice liver

Authors Witte S, Boshnakovska A, Özdemir M, Chowdhury A, Rehling P, Aich A   Journal Biology Open   Citation Biol Open. 2023 Mar 15;12(3):bio059844.   Abstract Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild
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13.03.2023

Bayesian MRI reconstruction with joint uncertainty estimation using diffusion models

Authors Luo G, Blumenthal M, Heide M, Uecker M   Journal Magnetic Resonance in Medicine   Citation Magn Reson Med. 2023 Mar 13.   Abstract Purpose: We introduce a framework that enables efficient sampling from learned probability distributions for MRI reconstruction. Method: Samples are drawn from the posterior distribution given
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09.03.2023

Excitation Intensity-Dependent Quantum Yield of Semiconductor Nanocrystals

Authors Ghosh S, Ross U, Chizhik AM, Kuo Y, Jeong BG, Bae WK, Park K, Li J, Oron D, Weiss S, Enderlein J, Chizhik AI Journal The Journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2023 Mar 9:2702-2707. Abstract One of the key phenomena that determine the fluorescence
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08.03.2023

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies

Authors Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank
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08.03.2023

Bioinspired Membrane Interfaces: Controlling Actomyosin Architecture and Contractility

Authors Liebe NL, Mey I, Vuong L, Shikho F, Geil B, Janshoff A, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2023 Mar 8;15(9):11586-11598. Abstract The creation of biologically inspired artificial lipid bilayers on planar supports provides a unique platform to study membrane-confined processes in
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Outcome of a previous Art of Brain Science event. Photo: Department of Experimental Neurodegeneration, UMG

07.03.2023

The Art of Brain Science

To connect neuroscience from around the world through visual and performance art. Science is founded on the creativity of the human mind, much like art. Spray painting is a versatile technique that is used at a global scale, to convey messages throughout history. In this event, art and neuroscience will
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