2023

05.04.2023

Fred Wolf receive Human Frontier Science Program funds

The first brains in the world of animals marked a decisive step in evolution. Living beings could now process information and identify opportunities as well as dangers. But how did the first brains evolve and what form did they take? MBExC member Fred Wolf from the University of Göttingen and

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05.04.2023

Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes

Authors Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, Liutkute A, Ritter M, Jung P, Stelzer L, Hüsgen LM, Klopp M, Rubio T, Fakuade FE, Mason FE, Hartmann N, Pabel S, Streckfuss-Bömeke K, Cyganek L, Sossalla S, Heijman J, Voigt N Journal Basic Research in Cardiology

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04.04.2023

Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain

Authors Schilbach S, Wang H, Dienemann C, Cramer P Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2220542120. Abstract For transcription initiation, RNA polymerase II (Pol II) forms a preinitiation complex (PIC) that associates with the general coactivator Mediator. Whereas

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04.04.2023

Cardiac patch in clinical trial: dose finding completed

The world’s only clinical trial in which patients with heart failure are implanted with artificial heart tissue to permanently strengthen the heart muscle has reached its first important milestone: the determination of the maximum safe dose was completed after treatment of 10 patients. The BioVAT-HF-DZHK20 study is conducted at the

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03.04.2023

Emilie Macé takes up new professorship for Dynamics of Excitable Cell Networks

Neuroscientist and expert in functional ultrasound bioimaging strengthens research profile of the Cluster of Excellence MBExC. (mbexc/umg) Prof. Dr. Emilie Macé has taken up the university professorship for Dynamics of Excitable Cell Networks at the University Medical Center Göttingen (UMG) on 1st April 2023. The professorship was newly established

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03.04.2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Authors Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D’Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M,

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01.04.2023

Welcome Prof. Dr. Emilie Macé at the MBExC

We are pleased to welcome Prof. Dr. Emilie Macé who took up the newly established professorship for “Dynamics of Excitable Cell Networks” at the University Medical Center on April 1st. With her expertise in functional ultrasound imaging that she pioneered, Emilie significantly strengthens the multiscale research approach of the MBExC.

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31.03.2023

Effects of cryo-EM cooling on structural ensembles

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what

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30.03.2023

Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins

Authors Hauke L, Isbaner S, Ghosh A, Guido I, Turco L, Chizhik AI, Gregor I, Karedla N, Rehfeldt F, Enderlein J Journal ACS Nano Citation ACS Nano. 2023 Mar 30. Abstract Metal-induced energy transfer (MIET) imaging is an easy-to-implement super-resolution modality that achieves nanometer resolution along the optical axis of

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29.03.2023

Breaking News’ best paper award 2023 for Lennart Roos and Inés Hojas Garcia-Plaza

Congratulations! Our Hertha Sponer College members Lennart Roos, clincian scientist at the MBExC, and Inés Hojas Garcia-Plaza, Ph.D. student at the MPI-NAT City Campus received the 1st and 2nd prize of the „Breaking News‘ Best Paper Award 2023“ at the 15th Göttingen Meeting of the German Neuroscience Society.

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