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30.06.2023

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

Authors Baeuerlein FJB, Renner M, El Chami D, Lehnart SE, Pastor-Pareja JC, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to voluminous biological specimens such
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29.06.2023

Translation termination in human mitochondria – substrate specificity of mitochondrial release factors

Authors Nadler F, Richter-Dennerlein R Journal Biological Chemistry Citation Biol Chem. 2023 Jun 29. Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to
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29.06.2023

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Authors Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich
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29.06.2023

State of Lower Saxony supports further preclinical development of optical cochlear implants

The State of Lower Saxony and the VolkswagenFoundation have granted researchers of the University Medical Center Göttingen, the Leibniz University Hannover and the Clusters of Excellence Multiscale Bioimaging and Hearing4all funding by the zukunft.niedersachsen program. Their project on the development of optical cochlear implants for the restoration of hearing in
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29.06.2023

State of Lower Saxony supports further preclinical development of optical cochlear implants

The State of Lower Saxony and the VolkswagenFoundation have granted researchers of the University Medical Center Göttingen, the Leibniz University Hannover and the Clusters of Excellence Multiscale Bioimaging and Hearing4all funding by the zukunft.niedersachsen program. Their project on the development of optical cochlear implants for the restoration of hearing in
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29.06.2023

Mechanisms of inward transmembrane proton translocation

Authors Kovalev K, Tsybrov F, Alekseev A, Shevchenko V, Soloviov D, Siletsky S, Bourenkov G, Agthe M, Nikolova M, von Stetten D, Astashkin R, Bukhdruker S, Chizhov I, Royant A, Kuzmin A, Gushchin I, Rosselli R, Rodriguez-Valera F, Ilyinskiy N, Rogachev A, Borshchevskiy V, Schneider TR, Bamberg E, Gordeliy V
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28.06.2023

Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson’s disease

Authors Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jun 28. Abstract The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to
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28.06.2023

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Authors Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP Journal Chemical Reviews Citation Chem Rev. 2023 Jun 28. Abstract Biomolecular condensates, membrane-less entities arising from liquid-liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions,
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26.06.2023

Structural insights into human co-transcriptional capping

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell. 2023 Jul 20;83(14):2464-2477.e5. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide
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