April 2023 – MBExC

29.04.2023

Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V

Authors Busley AV, Cyganek L Journal Stem Cell Research Citation Stem Cell Res. 2023 Jun;69:103108. Abstract Patients harboring causative gene variants in RAS GTPase MRAS develop Noonan syndrome and early-onset hypertrophic cardiomyopathy. Here, we describe the generation of a human iPSC line harboring the Noonan syndrome-associated MRAS p.G23V variant by

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28.04.2023

„The Art of Science“ – brain research meets street art

50 images from basic neuroscientific research were collected by employees of the Department of Experimental Neurodegeneration at the University Medical Center Göttingen (UMG) under the direction of MBExC member Prof. Dr. Tiago Outeiro and Dr. Anita Krisko and assembled into an installation. This installation served Malte Orth as the basis

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24.04.2023

Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V

Authors Busley AV, Kleinsorge M, Cyganek L Journal Stem Cell Research Citation Stem Cell Res. 2023 Apr 24;69:103105. Abstract Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. Here,

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24.04.2023

Quantitative Magnetic Resonance Imaging by Nonlinear Inversion of the Bloch Equations

Authors Scholand N, Wang X, Roeloffs V, Rosenzweig S, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2023 Apr 24. Abstract Purpose: Development of a generic model-based reconstruction framework for multiparametric quantitative MRI that can be used with data from different pulse sequences. Methods: Generic nonlinear model-based

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20.04.2023

Influence of phosphorylation on intermediate filaments

Authors Kraxner J, Köster S Journal Biological Chemistry Citation Biol Chem. 2023 Apr 20. Abstract The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety

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19.04.2023

Signatures of heterogeneity in the statistical structure of target state aligned ensembles

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.09719. Abstract Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that

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14.04.2023

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Authors Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann

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13.04.2023

A Bright Surprise: Live-Cell Labeling with Negatively Charged Fluorescent Probes based on Disulfonated Rhodamines and HaloTag

Authors Kim D, Stoldt S, Weber M, Jakobs S, Belov VN, Hell SW Journal Chemistry Methods Citation Chem. Methods 2023, e202200076. Abstract Disulfonated rhodamines are photostable and bright dyes widely used in life science and optical microscopy. However, di-sulfonated dyes were considered cell impermeable and not applicable

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13.04.2023

3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis

Authors Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, Salditt T Journal Neuroscience Citation Neuroscience. 2023 Apr 13:S0306-4522(23)00161-6. Abstract We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze

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12.04.2023

Andreas Janshoff and Martin Göpfert received Human Frontier Science Program funds

Researchers at Göttingen University are involved in research projects funded by Human Frontier Science Program. Biophysicist Professor and MBExC member Andreas Janshoff from the Faculty of Chemistry, together with researchers from the University of Warwick (who lead the project), the Hebrew University of Jerusalem, and Columbia University will investigate

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