2022

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21.04.2022

A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry

Authors Li F, Fornasiero EF, Dankovich TM, Kluever V, Rizzoli SO Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2022, 23, 4615. Abstract Nano secondary ion mass spectrometry (nanoSIMS) imaging is a rapidly growing field in biological sciences, which enables investigators to describe the chemical composition of
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21.04.2022

Background calcium influx in arrhythmia: lead actor or extra?

Authors Fakuade FE, Fauconnier J, Voigt N. Journal Journal of Physiology Citation J Physiol. 2022 Apr 21. Abstract No abstract available DOI 10.1113/JP283032 Pubmed Link  
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19.04.2022

Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Authors Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D Journal EMBO Reports Citation EMBO Rep. 2022 Apr 19:e53890. Abstract Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of
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15.04.2022

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Authors Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Qiu T, Kathayat RS, Dickinson BC, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R Journal Science Advances Citation Sci Adv. 2022 Apr 15;8(15):eabj8633. Abstract Genetic CLN5 variants are associated
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Indicated are the intracellular steps of the Gq signaling cascade, which can now be controlled by scientists using light to drive activity in transgenic mouse hearts (left) and contractions in the small intestine (right). Source: Prof. Brügmann / umg.

14.04.2022

A new tool for optogenetics: human receptor for studying cell function with light

Scientists of the University Medical Center Göttingen identify the human OPN5 receptor as a new target to activate cells and to study the principles of how cells communicate with each other. Published on 1 April 2022 in the renowned journal Nature Communications. Link to the MBExC press release
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Indicated are the intracellular steps of the Gq signaling cascade, which can now be controlled by scientists using light to drive activity in transgenic mouse hearts (left) and contractions in the small intestine (right). Source: Prof. Brügmann / umg.

14.04.2022

A new tool for optogenetics: human receptor for studying cell function with light

Scientists of the University Medical Center Göttingen identify the human OPN5 receptor as a new target to activate cells and to study the principles of how cells communicate with each other. Published on 1 April 2022 in the renowned journal Nature Communications. Gq proteins and the signaling cascade they trigger
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13.04.2022

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Authors Vincenti I, Page N, Steinbach K, Yermanos A, Lemeille S, Nunez N, Kreutzfeldt M, Klimek B, Di Liberto G, Egervari K, Piccinno M, Shammas G, Mariotte A, Fonta N, Liaudet N, Shlesinger D, Liuzzi AR, Wagner I, Saadi C, Stadelmann C, Reddy S, Becher B, Merkler D Journal Science
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11.04.2022

Retinal receptive-field substructure: scaffolding for coding and computation

Authors Zapp SJ, Nitsche S, Gollisch T Journal Trends in Neurosciences Citation Trends Neurosci. 2022 Apr 11:S0166-2236(22)00056-X. Abstract The center-surround receptive field of retinal ganglion cells represents a fundamental concept for how the retina processes and encodes visual information. Yet, traditional approaches of using the receptive field as a linear
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07.04.2022

Rapidly Signal-enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance

Authors Ding Y, Korchak S, Mamone S, Jagtap AP, Stevanato G, Sternkopf S, Moll D, Schroeder H, Becker S, Fischer A, Gerhardt E, Outeiro TF, Opazo F, Griesinger C, Glöggler S Journal Chemistry Methods Citation Chem. Methods 2022, e202200023. Abstract Nuclear magnetic resonance (NMR) is widely applied from analytics to
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04.04.2022

Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation – A proof-of-concept study

Authors Jebran AF, Tiburcy M, Biermann D, Balfanz P, Didié M, Karikkineth BC, Schöndube F, Kutschka I, Zimmermann WH Journal Journal of Molecular and Cellular Cardiology Citation J Mol Cell Cardiol. 2022 Apr 4;168:3-12. Abstract Engineered heart muscle (EHM) can be implanted epicardially to remuscularize the failing heart. In case
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