2021

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19.11.2021

Advanced Data Analysis for Fluorescence-Lifetime Single-Molecule Localization Microscopy

Authors Thiele JC, Nevskyi O, Helmerich DA, Sauer M, Enderlein J Journal Frontiers in Bioinformatics Citation Frontiers Bioinformatics 1, 56, (2021). Abstract Fluorescence-lifetime single molecule localization microscopy (FL-SMLM) adds the lifetime dimension to the spatial super-resolution provided by SMLM. Independent of intensity and spectrum, this lifetime information can be used,
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18.11.2021

Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review

Authors Müllenbroich MC, Kelly A, Acker C, Bub G, Bruegmann T, Di Bona A, Entcheva E, Ferrantini C, Kohl P, Lehnart SE, Mongillo M, Parmeggiani C, Richter C, Sasse P, Zaglia T, Sacconi L, Smith GL Journal Frontiers in Physiology Citation Front Physiol. 2021 Nov 18;12:769586. Abstract Optical techniques for
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Viola Priesemann. Photo: MPI-DS / Peter Heller

17.11.2021

Lower Saxony Science Award for Viola Priesemann

MBExC member Viola Priesemann has been awarded the Lower Saxony Science Award 2021 in the category “Scientist in an early career phase”. With this award, the Ministry of Science and Culture of Lower Saxony honored her professional achievements in the field of theoretical neuroscience, as well as the flexibility to
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15.11.2021

In memory of Ulf Diederichsen

The University of Göttingen is greatly saddened by the passing of the chemist and former Vice-President, Professor Ulf Diederichsen, who died on 11 November 2021. He has been very supportive to the MBExC. We are deeply saddened by his sudden death. Link to university press release
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15.11.2021

Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography

Authors Eckermann M, van der Meer F, Cloetens P, Ruhwedel T, Möbius W, Stadelmann C, Salditt T Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 7582-7598 (2021). Abstract In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto-
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11.11.2021

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Authors Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer
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11.11.2021

Structural basis of Integrator-mediated transcription regulation

Authors Fianu I, Chen Y, Dienemann Ch, Dybkov O, Linden A, Urlaub H, Cramer P Journal Science Citation Science. 2021 Nov 12;374(6569):883-887 Abstract Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the
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03.11.2021

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations

Authors Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz KL, Moretti A, Gummert JF, dos Remedios CG, Reinecke H, Knöll R, van
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01.11.2021

Protein Signatures of NK Cell-Mediated Melanoma Killing Predict Response to Immunotherapies

Authors Cappello S, Sung HM, Ickes C, Gibhardt CS, Vultur A, Bhat H, Hu Z, Brafford P, Denger A, Stejerean-Todoran I, Köhn RM, Lorenz V, Künzel N, Salinas G, Stanisz H, Legler T, Rehling P, Schön MP, Lang KS, Helms V, Herlyn M, Hoth M, Kummerow C, Bogeski I Journal
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31.10.2021

Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival

Authors Zelarayan L, Vendrell V, Domínguez-Frutos E, López-Hernández I, Schimmang-Alonso K, Alonso MT, Alvarez Y, Maier H, Anderson MJ, Lewandoski M, Schimmang T. Journal Developmental Dynamics Citation Dev Dyn. 2021 Oct 31. Abstract Background Fibroblast growth factors (Fgfs) are required for survival and organ formation during embryogenesis. Fgfs often execute
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