2021

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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life (Basel). 2021 Feb 11;11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of
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11.02.2021

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life. 2021; 11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination
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11.02.2021

Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming
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10.02.2021

The Coding And Small-Non-Coding Hippocampal Synaptic RNAome

Authors Epple R, Krüger D, Berulava T, Brehm G, Ninov M, Islam R, Köster S, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Feb 10. Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more
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10.02.2021

The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons

Authors Sertel SM, von Elling-Tammen MS, Rizzoli SO Journal Journal of Neuroscience Citation J Neurosci. 2021 Feb 10;41(6):1157-1173. Abstract The activity and the metabolism of the brain change rhythmically during the day/night cycle. Such rhythmicity is also observed in cultured neurons from the suprachiasmatic nucleus, which is a critical center
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"Heart patch" made from stem cells to repair the heart muscle in heart failure enters first clinical trial worldwide. Photo: umg

09.02.2021

“Heart patch” made from stem cells enters world’s first clinical trial

First application in humans: The BioVAT-HF-DZHK20 study intends to investigate the use of heart muscle tissue derived from stem cells for treatment of patients with severe heart failure. The incorporation of heart muscle tissue cultivated in the laboratory is intended to sustainably improve the pumping function of diseased hearts. The
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08.02.2021

Transcription activation depends on the length of the RNA polymerase II C-terminal domain

Authors Sawicka A, Villamil G, Lidschreiber M, Darzacq X, Dugast-Darzacq C, Schwalb B, Cramer P Journal EMBO Journal Citation EMBO J. 2021 Feb 8:e107015. Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail-like, intrinsically disordered carboxy-terminal domain (CTD) comprised of heptad-repeats, that functions in coordination of the transcription cycle
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08.02.2021

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling

Authors Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T Journal Development Citation Development. 2021 Feb 8;148(3):dev188276. Abstract Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels,
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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Synaptic diversity broadens the range of sound we can hear

Hearing occurs when sensory hair cells in the inner ear convert sound into neural signals transmitted to the brain. The sensory hair cells have about a dozen communication points with the auditory nerve fibers, called synapses. Scientists from the Institute for Auditory Neuroscience at the University Medical Center Göttingen discovered
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Scientists from Göttingen found that synapses on the abneural side (right side in the illustration) of the inner hair cell were active. They produced neurotransmitter release at weaker potentials than the ones on the neural side (left side). Figure: Özçete, UMG

05.02.2021

Synaptic diversity broadens the range of sound we can hear

Hearing occurs when sensory hair cells in the inner ear convert sound into neural signals transmitted to the brain. The sensory hair cells have about a dozen communication points with the auditory nerve fibers, called synapses. Scientists from the Institute for Auditory Neuroscience at the University Medical Center Göttingen discovered
Learn More
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