2021

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08.12.2021

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Authors Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO Journal Nature Communications Citation Nat Commun. 2021 Dec 8;12(1):7129. Abstract The brain extracellular matrix (ECM) consists of
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The fibres of the cytoskeleton (in blue) and the mitochondria (in yellow) are clearly visible in their structure due to the microscope used and the dyes that are (further) developed in parallel at abberior. Image: Francesca Bottanelli, FU Berlin, © abberior Instruments GmbH

03.12.2021

Technology transfer award for light microscopes with molecular resolution

For the entrepreneurial implementation of research results in the field of high-resolution light microscopy, abberior Instruments GmbH, the Max Planck Innovation GmbH and the Max Planck Institute for Biophysical Chemistry receive the technology transfer award from the German Physical Society. In 2012, abberior emerged from the NanoBiophotonics department of Nobel
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Dr. Funsho Fakuade, UMG, receives Dissertation Prize. Photo: MBExC.

02.12.2021

Funsho Fakuade receives Dissertation Prize

The MBExC congratulates Hertha Sponer College member Funsho Fakuade, Institute of Pharmacology and Toxicology at the UMG, for receiving the Dissertation Prize 2020 of the Universitätsbund Göttingen e.V. His excellently evaluated dissertation on the assessment of altered atrial physiology in patients with atrial fibrillation was chosen by a selection committee
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01.12.2021

Posterior analysis of n in the binomial (n,p) problem with both parameters unknown — with applications to quantitative nanoscopy

Authors Schmidt-Hieber J, Schneider LF, Staudt T, Krajina A, Aspelmeier T, Munk A Journal The Annals of Statistics Citation Ann. Statist. 49(6): 3534-3558 (December 2021). Abstract Estimation of the population size n from k i.i.d. binomial observations with unknown success probability p is relevant to a multitude of applications and
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30.11.2021

Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography

Authors Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A . 2021 Nov 30;118(48):e2113835118 Abstract We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in
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Foto: M. Eckermann/T. Salditt

26.11.2021

X-ray view of neurodegenerative diseases

Researchers at the University and University Medical Center Göttingen, in collaboration with the Cluster of Excellence Multiscale Bioimaging and the Collaborative Research Center Mathematics of Experimentation, have found a new way to measure and quantify neuronal tissue architecture in three dimensions and at high resolution. Using their specialized X-ray imaging,
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24.11.2021

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.
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f.l.: First author, Dr. Luis Daniel Cruz-Zaragoza, scientist at the Department of Cellular Biochemistry, UMG, and senior author, Prof. Dr. Peter Rehling, Director of the Department of Cellular Biochemistry, UMG. Photo: R. Yousefi, UMG.

23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”.   Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The
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f.l.: First author, Dr. Luis Daniel Cruz-Zaragoza, scientist at the Department of Cellular Biochemistry, UMG, and senior author, Prof. Dr. Peter Rehling, Director of the Department of Cellular Biochemistry, UMG. Photo: R. Yousefi, UMG.

23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”. Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The machinery
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Marmosets at the German Primate Center. Photo: Anton Säckl

22.11.2021

Gene therapy against deafness

One in 500 children is born with hearing impairment, and in 50 to 70 percent of cases a genetic defect is the cause. In a joint research project, a team led by Rüdiger Behr (German Primate Center) and MBExC spokesperson Tobias Moser (University Medical Center Göttingen) in cooperation with scientists
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