November

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30.11.2021

Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography

Authors Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A . 2021 Nov 30;118(48):e2113835118 Abstract We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in
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Foto: M. Eckermann/T. Salditt

26.11.2021

X-ray view of neurodegenerative diseases

Researchers at the University and University Medical Center Göttingen, in collaboration with the Cluster of Excellence Multiscale Bioimaging and the Collaborative Research Center Mathematics of Experimentation, have found a new way to measure and quantify neuronal tissue architecture in three dimensions and at high resolution. Using their specialized X-ray imaging,
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24.11.2021

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.
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f.l.: First author, Dr. Luis Daniel Cruz-Zaragoza, scientist at the Department of Cellular Biochemistry, UMG, and senior author, Prof. Dr. Peter Rehling, Director of the Department of Cellular Biochemistry, UMG. Photo: R. Yousefi, UMG.

23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”.   Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The
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f.l.: First author, Dr. Luis Daniel Cruz-Zaragoza, scientist at the Department of Cellular Biochemistry, UMG, and senior author, Prof. Dr. Peter Rehling, Director of the Department of Cellular Biochemistry, UMG. Photo: R. Yousefi, UMG.

23.11.2021

Targeting gene expression in mitochondria

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1190 develop novel strategy to investigate gene expression in mitochondria. Published in “Cell”. Mitochondria are considered the power plants of cells because they generate energy from our food with the help of oxygen. The machinery
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Marmosets at the German Primate Center. Photo: Anton Säckl

22.11.2021

Gene therapy against deafness

One in 500 children is born with hearing impairment, and in 50 to 70 percent of cases a genetic defect is the cause. In a joint research project, a team led by Rüdiger Behr (German Primate Center) and MBExC spokesperson Tobias Moser (University Medical Center Göttingen) in cooperation with scientists
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19.11.2021

Advanced Data Analysis for Fluorescence-Lifetime Single-Molecule Localization Microscopy

Authors Thiele JC, Nevskyi O, Helmerich DA, Sauer M, Enderlein J Journal Frontiers in Bioinformatics Citation Frontiers Bioinformatics 1, 56, (2021). Abstract Fluorescence-lifetime single molecule localization microscopy (FL-SMLM) adds the lifetime dimension to the spatial super-resolution provided by SMLM. Independent of intensity and spectrum, this lifetime information can be used,
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18.11.2021

Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review

Authors Müllenbroich MC, Kelly A, Acker C, Bub G, Bruegmann T, Di Bona A, Entcheva E, Ferrantini C, Kohl P, Lehnart SE, Mongillo M, Parmeggiani C, Richter C, Sasse P, Zaglia T, Sacconi L, Smith GL Journal Frontiers in Physiology Citation Front Physiol. 2021 Nov 18;12:769586. Abstract Optical techniques for
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Viola Priesemann. Photo: MPI-DS / Peter Heller

17.11.2021

Lower Saxony Science Award for Viola Priesemann

MBExC member Viola Priesemann has been awarded the Lower Saxony Science Award 2021 in the category “Scientist in an early career phase”. With this award, the Ministry of Science and Culture of Lower Saxony honored her professional achievements in the field of theoretical neuroscience, as well as the flexibility to
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15.11.2021

In memory of Ulf Diederichsen

The University of Göttingen is greatly saddened by the passing of the chemist and former Vice-President, Professor Ulf Diederichsen, who died on 11 November 2021. He has been very supportive to the MBExC. We are deeply saddened by his sudden death. Link to university press release
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