MBExC
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Optogenetics Club
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event speaker
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Sarah Köster
Ricarda Richter-Dennerlein
Housen Li
Hauke Hillen
Stefan Stoldt
Rubén Fernández-Busnadiego
Peter Rehling
Thomas Oertner
Tobias Moser
Julia Preobraschenski
Jörg Wegener
Han Chen
Vladan Rankovic
Antonio Martinez-Sanchez
Tiago Outeiro
Tim Salditt
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Cell biology
Cryo-electron tomography
Cell biology
Cryo-electron tomography
Past and Future Events
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july
Event Details
Prof. Dr. Walter Nickel from the Heidelberg University Biochemistry Center will held a talk about „Molecular mechanism and machinery driving unconventional
Event Details
Prof. Dr. Walter Nickel from the Heidelberg University Biochemistry Center will held a talk about „Molecular mechanism and machinery driving unconventional secretion of Fibroblast Growth Factor 2 from tumor cells“ during the MBExC Lecture on 7 July, 2025 at 3:00 p.m. at the library of the Humboldtallee 23, room 1.122.
Abstract:
The vast majority of secretory proteins contain N-terminal signal peptides for ER/Golgi-dependent transport into the extracellular space. Exceptions from this general mode of protein secretion from mammalian cells have been discovered more than 30 years ago, yet the molecular mechanisms underlying these alternative secretory pathways have remained elusive until recently. Proteins following such secretory routes have fundamental physiological functions in both health and disease, with Interleukin 1β and Fibroblast Growth Factor 2 being prime examples. The discoveries revealing the molecular mechanisms driving unconventional protein secretion did not only solve long-standing problems in molecular cell biology but also paved the way for new strategies for the treatment of for example inflammatory diseases and cancer.
Host: Prof. Dr. Peter Rehling, University Medical Center Göttingen
Organizer
MBExC
august
Event Details
Professor Karen Steel, PhD, FRS, FMedSci, from the Wolfson Sensory, Pain and Regeneration Centre, King’s College London will held a talk
Event Details
Professor Karen Steel, PhD, FRS, FMedSci, from the Wolfson Sensory, Pain and Regeneration Centre, King’s College London will held a talk about „Which types of hearing loss can be reversed?“ during the MBExC Lecture on 20 August, 2025 at 4:30 p.m. at the Michael Lankeit lecture hall, German Primate Center (DPZ), Kellnerweg 4.
Abstract
Progressive hearing loss is very common, particularly as people get older, and there are no medical treatments to slow down or stop the progression for the vast majority of cases. Hearing loss is highly heterogeneous, both in its causes and in the resulting pathology. Therefore, we are likely to need a range of different therapies for different causes and different sites-of-lesion within the inner ear. Some types of pathology may be treatable, even reversible, while other pathologies may not be treatable. Therefore, diagnosis of the cause, or at least the site-of-lesion, will be important to stratify patients for clinical trials, then to select the best treatment for each person. In this talk, I will summarise our understanding of the different ways we can lose our hearing, our progress using model systems to establish which types of pathology could be reversed, and how mouse mutants are giving us clues to how to distinguish different sites-of-lesion.
Host: Dr. Barbara Vona, UMG
Organizer
MBExC
september
202523sepAll Day25MBExC RetreatMBExC Retreat 2025(All Day) Schlosshotel Blankenburg
Event Details
The MBExC will meet for it’s yearly Retreat at the „Schlosshotel Blankenburg in Blankenburg, Harz from September 23 until 25, 2025. A joint journey will be organized.
Event Details
The MBExC will meet for it’s yearly Retreat at the „Schlosshotel Blankenburg in Blankenburg, Harz from September 23 until 25, 2025.
A joint journey will be organized.
We are very much looking forward to meet you at the retreat.
Organizer
MBExC