Omer Revah from the Hebrew University of Jerusalem will held a talk during the MBExC Lecture on 13 February, 2025 at 1 p.m. at the lecture hall, MPI-NAT City Campus, Hermann-Rein-Str. 3, 37075 Göttingen.

Host: Dr. Maria-Patapia Zafeiriou, University Medical Center Göttingen

Gemma Vilahur, Ph.D, FESC from the Research Institute Hospital de la Santa Creu i Sant Pau, Barcelona, Spain will held a talk about “Novel concepts in cardioprotection and ischemic heart disease: from pathophysiology to treatment” during the MBExC Lecture on 27 February, 2025 at 1:00 p.m.

Abstract
Ischemic heart disease remains the leading cause of morbidity and mortality globally, and the extent of myocardial infarction significantly influences the progression to heart failure. Currently, there is not therapeutic strategy available in the clinical setting able to limit infarct size. Consequently, extensive research has focused on identifying novel targets and developing innovative cardioprotective strategies to reduce cardiac damage and improve patient outcomes.
Recent advances in understanding the pathophysiological mechanisms behind myocardial infarction have led to new concepts in cardioprotection. Metabolic disturbances can heighten myocardial vulnerability during ischemic events and reduce the effectiveness of traditional treatments. A deeper exploration of how metabolic alterations impact cardioprotection has opened avenues for targeted interventions. Exploring the intricate relationship between comorbidities and cardiovascular health is crucial for crafting personalized cardioprotective strategies tailored to the patient’s needs.
Finally, beyond investigating new pharmacological targets, recent developments in therapeutic approaches—including pharmacological repositioning and lifestyle modifications—show promise for enhancing outcomes in patients with multiple health challenges. These strategies aim not only to boost cardioprotection but also to foster overall cardiovascular health, ultimately contributing to better long-term prognoses for individuals at risk of ischemic heart disease.

Host: Prof. Dr. Niels Voigt, University Medical Center Göttingen

Host: Jörg Enderlein (U GOE), MBExC
Local organizer: Alexander Egner (IFNANO)

Speaker: Carlas Smith, TU Delft

Host: Jörg Enderlein (U GOE), MBExC
Local organizer: Alexander Egner (IFNANO)

Speaker: Prof. Guillermo Pedro Acuna, Photonic Nanosystems, University of Fribourg

Abstract:
Developments in low-cost microscopy have accelerated greatly in recent years due to the technological advances of modern smartphones. Among different features, these devices have image sensors with more pixels, better quantum efficiencies, better optics design for light collection, and larger focal distances in different lenses of multi-camera smartphones. Distinct aspects of smartphones, i.e., portability and compactness, have also pushed forward the development of specific smartphone-based setups useful in Point-Of-Care (POC) applications like clinical diagnostics, quantification of immunoassays, detection of bacteria, cancer cytology, fresh tissue imaging, lead and microplastics quantification. While most of these applications used optical setups designed for fluorescence imaging, only a few of them focused on the detection of single molecule fluorescence.
Here, we developed a portable and inexpensive smartphone-based fluorescence microscope that detects direct emission from single molecules. We tested its performance by analyzing single-molecule intensity traces with three smartphones. We also demonstrated that it can be used for super-resolution microscopy with a Single-Molecule Localization Microscopy (SMLM), DNA-PAINT. The smartphone-based microscope we present is low-cost, portable, easy to use, and can virtually be used with any smartphone, making an impact on a truly broad audience.

Please find here the PDF of the announcement: