Pape, Constantin

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24.03.2026

A correlative workflow for synaptic imaging by cryo-electron tomography

Authors Do TT, Siegert A, Domart F, Hahn F, Zeising C, Muth S, Pape C, Kusch K, Dresbach T, Rizzoli SO, Petrovic A, Fernández-Busnadiego R Journal Structure Citation Structure. 2026 Mar 24:S0969-2126(26)00059-6. Abstract Despite decades of intense research, the molecular organization of the synapse is not well understood. To address
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20.03.2026

Evaluating Vision Foundation Models for Pixel and Object Classification in Microscopy

Authors Teuber C, Archit A, Boothe T, Ditte P, Rink J, Pape C Journal Arxiv Citation arXiv:2603.19802. Abstract Deep learning underlies most modern approaches and tools in computer vision, including biomedical imaging. However, for interactive semantic segmentation (often called pixel classification in this context) and interactive object-level classification (object classification),
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18.03.2026

Revisiting foundation models for cell instance segmentation

Authors Archit A, Pape C Journal Arxiv Citation arXiv:2603.17845. Abstract Cell segmentation is a fundamental task in microscopy image analysis. Several foundation models for cell segmentation have been introduced, virtually all of them are extensions of Segment Anything Model (SAM), improving it for microscopy data. Recently, SAM2 and SAM3 have
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17.12.2025

BioimageAIpub: a toolbox for AI-ready bioimaging data publishing

Authors Dvoretskii S, Archit A, Pape C, Moore J, Nolden M Journal Arxiv Citation arXiv:2512.15820. Abstract Modern bioimage analysis approaches are data hungry, making it necessary for researchers to scavenge data beyond those collected within their (bio)imaging facilities. In addition to scale, bioimaging datasets must be accompanied with suitable, high-quality
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17.12.2025

MedicoSAM: Robust Improvement of SAM for Medical Imaging

Authors Archit A, Freckmann L, Pape C Journal IEEE Transactions on Medical Imaging Citation IEEE Trans Med Imaging. 2025 Dec 17;PP. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models
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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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17.10.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Sciende Advances Citation Sci Adv. 2025 Oct 17;11(42):eady8532. Abstract Hearing
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28.08.2025

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal Molecular Biology of the
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26.08.2025

A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space

Authors Harland LTG, Lohoff T, Koulena N, Pierson N, Pape C, Ameen F, Griffiths J, Theeuwes B, Wilson NK, Kreshuk A, Reik W, Nichols J, Cai L, Marioni JC, Göttgens B, Ghazanfar S Journal Cell Reports Citation Cell Rep. 2025 Aug 26;44(8):116047. Abstract During gastrulation, mouse epiblast cells form the
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12.07.2025

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal Nature Communications Citation Nat Commun. 2025 Jul 12;16(1):6450. Abstract Activity recognition in live-cell imaging is labor-intensive
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