Fischer, André

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18.09.2024

Plasma miRNAs across the Alzheimer’s disease continuum: Relationship to central biomarkers

Authors Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K; Alzheimer’s Disease Neuroimaging Initiative Journal
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12.09.2024

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.09.12.612649. Abstract N6-methyladenosine (m6A) is the most abundant and conserved transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A in the development of
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29.08.2024

Blood-derived microRNAs are related to cognitive domains in the general population

Authors Melas K, Talevi V, Imtiaz MA, Etteldorf R, Estrada S, Krüger DM, Pena-Centeno T, Aziz NA, Fischer A, Breteler MMB Journal Alzheimer’s & Dementia Citation Alzheimers Dement. 2024 Aug 29. Abstract Introduction: Blood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous
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29.08.2024

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

Authors Gather F, Rauleac T, Akol I, Arumugam G, Fullio CL, Müller T, Kleidonas D, Fischer A, Vlachos A, Backofen R, Vogel T Journal BioRxiv Citation bioRxiv 2024.08.29.610239. Abstract Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and posttranscriptional processes, can cause diverse neurodevelopmental diseases (NDD).
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29.08.2024

PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease

Authors Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A Journal Acta Neuropahologica Citation Acta Neuropathol. 2024 Aug 29;148(1):32. Abstract Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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19.07.2024

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Authors Talevi V, Melas K, Pehlivan G, Imtiaz MA, Krüger DM, Centeno TP, Aziz NA, Fischer A, Breteler MMB Journal Journal of Translational Medicine Citation J Transl Med. 2024 Jul 19;22(1):670. Abstract Background: As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several
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04.06.2024

Effective exosomes reduction in hypercholesterinemic patients suffering from cardiovascular diseases by lipoprotein apheresis: Exosomes apheresis

Authors Schröder S, Epple R, Fischer A, Schettler VJJ Journal Therapeutic Apheresis and Dialysis Citation Ther Apher Dial. 2024 Jun 4. Abstract Introduction: Extracellular vesicles (EVs) have been identified as playing a role in atherosclerosis. Methods: A group of 37 hypercholesterolemic patients with atherosclerotic cardiovascular diseases (ASCVD) and 9 patients
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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J   Journal Nature   Citation Nature. 2024 Apr;628(8006):145-153.   Abstract As hippocampal neurons respond to diverse types
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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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