Fischer, André

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11.05.2026

Systematic review and transcriptomic meta-analysis of environmental enrichment reveal core molecular programs of brain plasticity

Authors Kurowska M, Miozzo F, Schroeder R, Machnicka MA, Pérez-González R, Merienne K, Fischer A, Barco A, Boutillier AL, Wilczyński B Journal BioRxiv Citation bioRxiv 2026.05.10.724097 Abstract RATIONALE: Environmental enrichment (EE) paradigms in rodents have long demonstrated that enhanced sensory, cognitive, social, and motor stimulation positively impacts brain function, improving
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06.05.2026

The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2026 May 6. Abstract N6-methyladenosine (m6A) is the most abundant transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A
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01.05.2026

The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies

Authors Navarro-Flores A, Krüger DM, Kaurani L, Fischer A, Schulze TG, Heilbronner U Journal Molecular Psychiatry Citation Mol Psychiatry. 2026 May 1. Abstract Executive functions (EFs) are meta-cognitive abilities that orchestrate goal-directed behavior (i.e., set-shifting, working memory, and inhibitory control). Despite their strong genetic composition, the development of EFs is
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24.04.2026

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: Findings from the Rhineland Study

Authors Melas K, Talevi V, Imtiaz MA, Krüger DM, Pena-Centeno T, Fischer A, Aziz NA, Breteler MMB Journal Molecular Psychiatry Citation Mol Psychiatry. 2026 Apr 24. Abstract MicroRNAs (miRNAs) have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal
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25.03.2026

lncRNA Glelr modulates microglia inflammatory programs in association with PU.1

Authors Pradhan R, Sakib MS, Kaurani L, Krüger DM, Pena T, Burkhardt S, Schütz AL, Kronenberg-Versteeg D, Delalle I, Sananbenesi F, Fischer A Journal Neurobiology of Disease Citation Neurobiol Dis. 2026 Mar 25;222:107366. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to
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14.03.2026

Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer’s Disease

Authors Pradhan R, Petrovic Z, Sadman Sakib M, Schröder S, Manfred Krüger D, Pena T, Diniz E, Burkhardt S, Schütz AL, Gisa V, Grzadzielewska I, Toischer K, Stein TD, Krzysztof Blusztajn J, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal Advanced Science (Weinheim) Citation Adv Sci (Weinh). 2026 Mar
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10.02.2026

Multi-scale transcriptomic integration reveals cell-type immune networks and lncRNA remodeling in Alzheimers disease

Authors Cortes Silva JA, Gertig M, Centeno TP, Burkhardt S, Schutz AL, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.02.08.704661. Abstract Alzheimers disease (AD) displays pronounced regional heterogeneity, yet how transcriptional changes across brain regions converge into coordinated cellular and molecular programs remains unclear. Here, we integrated bulk and
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02.12.2025

Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment

Authors Annamalai K, Dilliker S, Buchholz E, Castro-Hernández R, Panyam N, Pommeranz A, Wiederhake P, Wery von Limont N, Hempel N, Ebner V, Swarnkar S, Mohamed BA, Streckfuss-Bömeke K, Steffens S, Herzig S, Ebert A, Fischer A, Toischer K Journal Cell Communication and Signaling Citation Cell Commun Signal. 2025 Dec
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01.11.2025

lncRNA 3222401L13Rik/ENSG00000272070 modulates microglial inflammatory programs in association with PU.1

Authors Pradhan R, Sakib MS, Kaurani L, Krueger DM, Pena T, Burckhardt S, Schuetz AL, Kronenberg-Verstee D, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.10.31.685723. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease
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24.10.2025

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling

Authors Ulmke PA, Sakib MS, Nguyen DT, Muchamedin A, Sokpor G, Pham L, Xie Y, Abbas E, Castro Hernandez R, Narayanan R, Wincent J, Liedén A, Harris E, Joss S, Fischer A, Staiger JF, Nguyen HP, Tuoc T Journal Brain Citation Brain. 2025 Oct 24:awaf405. Abstract The evolutionarily conserved RNA
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