Brose, Nils

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03.04.2024

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

Authors López-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H   Journal Proceedings of the National Academy of Sciences of the United States of America   Citation Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320505121.   Abstract The presynaptic
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27.12.2023

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses

Authors Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos
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12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
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08.12.2023

Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Authors Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T Journal Protein & Cell Citation Protein & Cell. 2023 Dec 8:pwad058. accepted manuscript.
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30.11.2023

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Authors Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A,
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30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,
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18.11.2022

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

Authors Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS Journal eLife Citation eLife 11:e79077. Abstract Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and
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31.05.2022

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed
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19.01.2022

Molecular and functional architecture of striatal dopamine release sites

Authors Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen RL, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS Journal Neuron Citation Neuron. 2022 Jan 19;110(2):248-265.e9. Abstract Despite the importance of dopamine for striatal circuit function, mechanistic understanding
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21.10.2021

Munc13-1 is a Ca 2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission

Authors Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N Journal Neuron Citation Neuron. 2021 Oct 21:S0896-6273(21)00727-3. Abstract During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to release
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