Alekseev, Alexey

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02.05.2025

Structural basis for no retinal binding in flotillin-associated rhodopsins

Authors Kovalev K, Stetsenko A, Trunk F, Marin E, Haro-Moreno JM, Lamm GHU, Alekseev A, Rodriguez-Valera F, Schneider TR, Wachtveitl J, Guskov A Journal BioRxiv Citation bioRxiv 2025.04.29.651185. Abstract Rhodopsins are light-sensitive membrane proteins capturing solar energy via a retinal cofactor covalently attached to a lysine residue. Several groups of
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18.04.2025

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport

Authors Bukhdruker S, Gushchin I, Shevchenko V, Kovalev K, Polovinkin V, Tsybrov F, Astashkin R, Alekseev A, Mikhaylov A, Bukhalovich S, Bratanov D, Ryzhykau Y, Kuklina D, Caramello N, Rokitskaya T, Antonenko Y, Rulev M, Stoev C, Zabelskii D, Round E, Rogachev A, Borshchevskiy V, Ghai R, Bourenkov G, Zeghouf
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23.12.2024

Efficient and sustained optogenetic control of sensory and cardiac systems

Authors Alekseev A, Hunniford V, Zerche M, Jeschke, M, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Meyer A, Rambousky A, Alvanos T, Witzke I, Rojas-Garcia KD, Draband M, Cyganek L, Klein E, Ruther P, Huet A, Trenholm S, Macé E, Kusch K, Bruegmann T,
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10.04.2024

A subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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10.04.2024

A novel subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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02.01.2024

Hijacking of internal calcium dynamics by intracellularly residing viral rhodopsins

Authors Eria-Oliveira AS, Folacci M, Chassot AA, Fedou S, Thézé N, Zabelskii D, Alekseev A, Bamberg E, Gordeliy V, Sandoz G, Vivaudou M Journal Nature Communications Citation Nat Commun. 2024 Jan 2;15(1):65. Abstract Rhodopsins are ubiquitous light-driven membrane proteins with diverse functions, including ion transport. Widely distributed, they are also
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29.06.2023

Mechanisms of inward transmembrane proton translocation

Authors Kovalev K, Tsybrov F, Alekseev A, Shevchenko V, Soloviov D, Siletsky S, Bourenkov G, Agthe M, Nikolova M, von Stetten D, Astashkin R, Bukhdruker S, Chizhov I, Royant A, Kuzmin A, Gushchin I, Rosselli R, Rodriguez-Valera F, Ilyinskiy N, Rogachev A, Borshchevskiy V, Schneider TR, Bamberg E, Gordeliy V
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24.05.2023

Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Authors Haro-Moreno JM, López-Pérez M, Alekseev A, Podoliak E, Kovalev K, Gordeliy V, Stepanauskas R, Rodriguez-Valera F Journal mSystems Citation mSystems. 2023 May 24:e0000823. Abstract Microbial rhodopsins are found more than once in a single genome (paralogs) often have different functions. We screened a large dataset of open ocean single-amplified
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