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08.06.2022

Retinal Encoding of Natural Scenes

Authors Karamanlis D, Schreyer HM, Gollisch T Journal Annual Review of Vision Science Citation Annu Rev Vis Sci. 2022 Jun 8. Abstract An ultimate goal in retina science is to understand how the neural circuit of the retina processes natural visual scenes. Yet most studies in laboratories have long been
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07.06.2022

Progressive frontal intraosseous lipoma: Detection of the mosaic AKT1 variant discloses Proteus syndrome

Authors Schmidt J, Bremmer F, Brockmann K, Kaulfuß S, Wollnik B Journal Clinical Genetics Citation Clin Genet. 2022 Jun 7. Abstract Proteus syndrome is a very rare disorder with progressive, asymmetrical, and disproportionate overgrowth of body parts with a highly variable phenotype. It is associated with mosaicism for the recurrent
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06.06.2022

Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway

Authors Farkas Á, Urlaub H, Bohnsack KE, Schwappach B Journal Journal of Cell Biology Citation J Cell Biol. 2022 Jun 6;221(6):e202201036. Abstract The guided entry of tail-anchored proteins (GET) pathway targets C-terminally anchored transmembrane proteins and protects cells from lipotoxicity. Here, we reveal perturbed ergosterol production in ∆get3 cells and
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03.06.2022

Synaptic transmission at the vestibular hair cells of amniotes

Authors Mukhopadhyay M, Pangrsic T Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2022 Jun 3;121:103749. Abstract A harmonized interplay between the central nervous system and the five peripheral end organs is how the vestibular system helps organisms feel a sense of balance and motion in three-dimensional space. The
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02.06.2022

Measuring photophysical transition rates with fluorescence correlation spectroscopy and antibunching

Authors Sakhapov D, Gregor I, Karedla N, Enderlein J Journal Journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2022 Jun 2;13(21):4823-4830. Abstract We present a new method that combines fluorescence correlation spectroscopy (FCS) on the microsecond time scale with fluorescence antibunching measurements on the nanosecond time scale for
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02.06.2022

The relevance of synuclein autoantibodies as a biomarker for Parkinson’s disease

Authors Garg P, Maass F, Sundaram SM, Mollenhauer B, Mahajani S, van Riesen C, Kügler S, Bähr M Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2022 Jun 2:103746. Abstract Several studies have investigated if the levels of α-synuclein autoantibodies (α-syn AAb) differ in serum of Parkinson’s disease (PD)
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02.06.2022

Resolving the molecular architecture of the photoreceptor active zone by 3D-MINFLUX

Authors Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T Journal Science Advances Citation Sci Adv. 2022 Jul 15;8(28):eabl7560. Abstract Cells assemble macromolecular complexes into scaffoldings that serve as substrates for catalytic processes. Years of molecular neurobiology indicate that neurotransmission depends on such
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01.06.2022

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

Authors Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A Journal eBioMedicine Citation EBioMedicine. 2022 Jun;80:104021 Abstract Background: Synucleinopathies such as Parkinson ́ s disease
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01.06.2022

Statistical Methods for Minimax Estimation in Linear Models with Unknown Design Over Finite Alphabets

Authors Behr M, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 4(2):490-513. Abstract We provide a minimax optimal estimation procedure for F and W in matrix valued linear models Y = F W + Z where the parameter matrix W
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31.05.2022

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed
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