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11.09.2023

Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis

Authors Kanwischer L, Xu X, Saifuddin AB, Maamari S, Tan X, Alnour F, Tampe B, Meyer T, Zeisberg M, Hasenfuss G, Puls M, Zeisberg EM Journal Clinical Epigenetics Citation Clin Epigenetics. 2023 Sep 11;15(1):149. Abstract Background: Aortic stenosis (AS) is one of the most common cardiac diseases and major cause
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09.09.2023

An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex

Authors Enz LS, Winkler A, Wrzos C, Dasen B, Nessler S, Stadelmann C, Schaeren-Wiemers N Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2023 Sep 9;24(18):13893. Abstract Modeling chronic cortical demyelination allows the study of long-lasting pathological changes observed in multiple sclerosis such as failure of remyelination,
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07.09.2023

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development

Authors Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann
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06.09.2023

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand
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05.09.2023

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex
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03.09.2023

Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).

Authors Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Sep 3. Abstract The receptor for advanced glycation end products (RAGE) is a protein of the
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30.08.2023

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

Authors Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein A, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M Journal iScience Citation iScience. 2023 Aug 30;26(10):107786. Abstract N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing
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30.08.2023

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease

Authors Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(17) Abstract Parkinson’s disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites
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25.08.2023

En route to sound coding strategy for optical cochlear implants

Authors Khurana L, Harczos T, Moser T, Jablonski L Journal iScience Citation iScience (2023). Abstract In 2019, disabling hearing loss affected 430 million people worldwide and will reach over 700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by electrical cochlear implants (eCIs) bypassing dysfunctional or lost hair
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25.08.2023

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Authors Yamamoto H, Spitzner FP, Takemuro T, Buendía V, Murota H, Morante C, Konno T, Sato S, Hirano-Iwata A, Levina A, Priesemann V, Muñoz MA, Zierenberg J, Soriano J Journal Science Advances Citation Sci Adv. 2023 Aug 25;9(34):eade1755. Abstract High-level information processing in the mammalian cortex requires both segregated processing
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