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24.03.2026

A correlative workflow for synaptic imaging by cryo-electron tomography

Authors Do TT, Siegert A, Domart F, Hahn F, Zeising C, Muth S, Pape C, Kusch K, Dresbach T, Rizzoli SO, Petrovic A, Fernández-Busnadiego R Journal Structure Citation Structure. 2026 Mar 24:S0969-2126(26)00059-6. Abstract Despite decades of intense research, the molecular organization of the synapse is not well understood. To address
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23.03.2026

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

Authors Mukhopadhyay M, Modgekar R, Yang-Hood A, Ohlemiller KK, Militchin V, Xiao M, Shen Z, Rensing NR, Wong M, Lee SJ, Seal RP, Holt JC, Warchol ME, Maloney SE, Yuede CM, Rutherford MA, Pangrsic T Journal Scientific Reports Citation Sci Rep. 2026 Mar 23. Abstract Quantal synaptic transmission in vestibular
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20.03.2026

Evaluating Vision Foundation Models for Pixel and Object Classification in Microscopy

Authors Teuber C, Archit A, Boothe T, Ditte P, Rink J, Pape C Journal Arxiv Citation arXiv:2603.19802. Abstract Deep learning underlies most modern approaches and tools in computer vision, including biomedical imaging. However, for interactive semantic segmentation (often called pixel classification in this context) and interactive object-level classification (object classification),
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19.03.2026

Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Authors Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T, Ecker AS Journal eNeuro Citation eNeuro. 2026 Mar 19:ENEURO.0060-26.2026. Abstract The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, and
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18.03.2026

Revisiting foundation models for cell instance segmentation

Authors Archit A, Pape C Journal Arxiv Citation arXiv:2603.17845. Abstract Cell segmentation is a fundamental task in microscopy image analysis. Several foundation models for cell segmentation have been introduced, virtually all of them are extensions of Segment Anything Model (SAM), improving it for microscopy data. Recently, SAM2 and SAM3 have
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17.03.2026

Myosin II-driven contractions of supporting cap cells promote sensory adaptation of Drosophila proprioceptors

Authors Guan C, Nishi K, Kreis CT, Bäumchen O, Göpfert MC, Schmidt CF Journal Current Biology Citation Curr Biol. 2026 Mar 17:S0960-9822(26)00223-X. Abstract Mechanoreceptors can be motile and actively amplify their mechanical input.1,2,3,4 We here found that the responses of mechanoreceptor cells can also be shaped actively by contractile supporting
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17.03.2026

Early demyelination by off-target complement injury in a mouse model of neuromyelitis optica

Authors Kenet S, Herwerth M, Askari S, Eichenseer K, Dornmair K, Qin X, Stadelmann C, Bennett JL, Hemmer B, Misgeld T Journal BioRxiv Citation bioRxiv 2026.03.13.711636. Abstract Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune CNS disease characterized by serum antibodies targeting astrocytes for complement-mediated lysis. NMOSD lesions show not
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14.03.2026

Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer’s Disease

Authors Pradhan R, Petrovic Z, Sadman Sakib M, Schröder S, Manfred Krüger D, Pena T, Diniz E, Burkhardt S, Schütz AL, Gisa V, Grzadzielewska I, Toischer K, Stein TD, Krzysztof Blusztajn J, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal Advanced Science (Weinheim) Citation Adv Sci (Weinh). 2026 Mar
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12.03.2026

Neuroinflammatory profiles and cellular localization of TNF-α associated with chronic vanadium neurotoxicity

Authors Folarin RO, Olopade FE, Gilbert TT, Ladagu AD, Dos Santos PIP, Mustapha OA, Kpasham LZ, Outeiro TF, Olopade JO Journal Metabolic Brain Disease Citation Metab Brain Dis. 2026 Mar 12;41(1):52. Abstract Vanadium, an environmental pollutant, is closely associated with neurodegeneration, primarily through oxidative damage and chronic neuroinflammation. While chronic
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10.03.2026

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Mohseni F, Vukušić K, Tirincsi A, Wardenaar R, Losito M, Harmsen I, Gönenc II, Wollnik B, Foijer F, Tolić IM, Storchová Z, Räschle M Journal Nucleid Acid Research Citation Nucleic Acids Res. 2026 Feb 24;54(5):gkag199. Abstract The BLM helicase is a critical genome maintenance protein
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