2025

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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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14.11.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BMC Biology Citation BMC Biol. 2025 Nov 14;23(1):340. Abstract Background: The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the
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13.11.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Müller GF, Roos L, Li J, Göpel T, Weiss KR, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal Nature Biotechnology Citation Nat Biotechnol. 2025 Nov 13. Abstract Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for
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05.11.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MADRBF, Esch K, Ruhwedel T, Möbius W, Wolf F, Moser T Journal Science Advances Citation Sci. Adv.11,eady4344(2025). Abstract The cochlea encodes sounds into neural signals at the synapses of inner hair cells (IHCs) and spiral ganglion neurons (SGNs) with remarkable fidelity. To
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04.11.2025

Redundancy Maximization as a Principle of Associative Memory Learning

Authors Blümel M, Schneider AC, Neuhaus V, Ehrlich DA, Graetz M, Wibral M, Makkeh A, Priesemann V Journal Arxiv Citation arXiv:2511.02584 Abstract Associative memory, traditionally modeled by Hopfield networks, enables the retrieval of previously stored patterns from partial or noisy cues. Yet, the local computational principles which are required to
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01.11.2025

lncRNA 3222401L13Rik/ENSG00000272070 modulates microglial inflammatory programs in association with PU.1

Authors Pradhan R, Sakib MS, Kaurani L, Krueger DM, Pena T, Burckhardt S, Schuetz AL, Kronenberg-Verstee D, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.10.31.685723. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease
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29.10.2025

Testing Paradox May Explain Increased Observed Prevalence of Bacterial STIs among MSM on HIV PrEP: A Modeling Study

Authors Müller L, Mallick P, Marín-Carballo AB, Dönges P, Kettlitz RJN, Klett-Tammen CJ, Kretzschmar M, Priesemann V, Contreras S Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Nov 4;122(44):e2524944122. Abstract HIV pre-exposure prophylaxis (PrEP) is
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29.10.2025

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

Authors Feng R, Spieth L, Liu L, Berghoff S, Franz J, Liu Q, Wang Z, Tiwari V, Vitale S, Frerich S, Florensa S, Junker N, Huber L, Keller M, Müller C, Bracher F, Ge X, Rensen PCN, Kooij G, Hosang L, Chornyi S, Dichgans M, Gokce O, Saher G, Stadelmann
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27.10.2025

Leonardo: a toolset to correct sample-induced artifacts in light sheet microscopy images

Authors Liu Y, Mueller GF, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roessing M, Stenzel M, Grueneboom A, Paetzold J, Erturk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal BioRxiv Citation bioRxiv 2025.10.26.684661. Abstract Selective plane illumination microscopy (SPIM, also known as light
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25.10.2025

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

Authors Zhao XT, Diep DTV, Percifull L, Fausten RM, Hugenroth M, Höhne P, Leite B, Esch BM, Collado J, Keller J, Wilmes S, Turhan MA, Wälte M, Becker T, Kümmel D, Schuberth C, Fernández-Busnadiego R, Fröhlich F, Wedlich-Söldner R, Bohnert M Journal Cell Reports Citation Cell Rep. 2025 Oct 25;44(11):116475.
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