Latest Publications

Authors Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH, Lutz S Journal Journal of Visualized Experiments Citation J Vis Exp. 2021 Aug 20;(174). Abstract Fibroblasts are phenotypically highly dynamic cells, which quickly transdifferentiate into myofibroblasts in response to biochemical and biomechanical stimuli. The current understanding of fibrotic processes,

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of

Authors Khuller K, Yigit G, Grijalva CM, Altmüller J, Thiele H, Nürnberg P, Elcioglu NH, Yeter B, Hehr U, Stein A, Della Marina A, Köninger A, Depienne C, Kaiser FJ, Wollnik B, Kuechler A Journal European Journal of Medical Genetics Citation Eur J Med Genet. 2021 Aug 13:104310. Abstract MFSD2A,

Authors Steinmetz M, Stümpfig T, Seehase M, Schuster A, Kowallick J, Müller M, Unterberg-Buchwald C, Kutty S, Lotz J, Uecker M, Paul T Journal Circulation: Cardiovascular Imaging Citation Circ Cardiovasc Imaging. 2021 Aug;14(8):e011823. Abstract Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular

Authors Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2021). 2021 Aug 11. Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of

Authors Bäuerlein FJB, Baumeister W Journal Journal of Molecular Biology Citation J Mol Biol. 2021 Aug 9:167187. Abstract Traditionally, structural biologists approach the complexity of cellular proteomes in a reductionist manner. Proteomes are fractionated, their molecular components purified and studied one-by-one using the experimental methods for structure determination at their

Authors Ghosh A, Enderlein J Journal Current Opinion in Structural Biology Citation Curr Opin Struct Biol. 2021 Aug 6;70:123-131. Abstract We present the recent developments and advances in fluorescence correlation spectroscopy (FCS) and their application to the investigation of biomolecular conformations. In particular, we present and discuss three techniques: multichannel

Authors Zimmermann WH Journal Cardiovascular Research Citation Cardiovasc Res. 2021 Aug 4:cvab229. Abstract No Abstract available. DOI 10.1093/cvr/cvab229 Pubmed Link  

Authors Sievers K, Welp L, Urlaub H, Ficner R Journal RNA Biology Citation RNA Biol. 2021 Jul 31:1-15. Abstract The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr. While both subunits of the functional heterodimer have been crystallized individually,

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Jul 27;55:102473. Abstract Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and