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27.12.2022

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Authors Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. Abstract Capturing mitochondria’s intricate and dynamic
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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23.12.2022

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)
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22.12.2022

On the Fabrication and Characterization of Polymer-Based Waveguide Probes for Use in Future Optical Cochlear Implants

Authors Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D Journal Materials (Basel) Citation Materials (Basel). 2022 Dec 22;16(1):106. Abstract Improved hearing restoration by cochlear implants (CI) is expected
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16.12.2022

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Authors Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2022;12(8):2397-2422. Abstract Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between
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12.12.2022

Mono- and Intralink Filter (Mi-Filter) To Reduce False Identifications in Cross-Linking Mass Spectrometry Data

Authors Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F Journal Analytical Chemistry Citation Anal. Chem. 2022, 94, 51, 17751–17756. Abstract Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However,
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08.12.2022

Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

Authors Galbusera R, Bahn E, Weigel M, Schaedelin S, Franz J, Lu PJ, Barakovic M, Melie-Garcia L, Dechent P, Lutti A, Sati P, Reich DS, Nair G, Brück W, Kappos L, Stadelmann C, Granziera C. Journal Brain Pathology Citation Brain Pathol. 2022 Dec 8:e13136. Abstract Quantitative MRI (qMRI) probes the
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07.12.2022

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in
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06.12.2022

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation

Authors Voigt N, Maack C, Pronto JRD Journal Journal of the American College of Cardiology Citation J Am Coll Cardiol. 2022 Dec, 80 (23) 2220–2223. Abstract No abstract available DOI 10.1016/j.jacc.2022.09.043   Pubmed Link
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29.11.2022

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

Authors Pinheiro Neto J, Spitzner FP, Priesemann V Journal PLoS Computational Biology Citation PLoS Comput Biol 18(11): e1010678. Abstract To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity
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