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12.06.2023

Membrane-Bound Vimentin Filaments Reorganize and Elongate under Strain

Authors Nageswaran S, Haipeter J, Bodenschatz JFE, Meyer R, Köster S, Steinem C Journal Biomacromolecules Citation Biomacromolecules. 2023 Jun 12;24(6):2512-2521. Abstract Within a cell, intermediate filaments interact with other cytoskeletal components, altogether providing the cell’s mechanical stability. However, little attention has been drawn to intermediate filaments close to the plasma
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12.06.2023

The promise of optogenetic arrhythmia termination

Authors Bruegmann T, Sacconi L Journal Journal of Internal Medicine Citation J Intern Med. 2023 Jun 12. Abstract No abstract available. DOI 10.1111/joim.13680   Pubmed Link
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07.06.2023

N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing

Authors Wang C, Ulryck N, Herzel L, Pythoud N, Kleiber N, Guérineau V, Jactel V, Moritz C, Bohnsack MT, Carapito C, Touboul D, Bohnsack KE, Graille M Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Jun 7:gkad487. Abstract Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent
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29.05.2023

Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1

Authors Dennerlein S, Rehling P, Richter-Dennerlein R Journal FEBS Letters Citation FEBS Lett. 2023 May 29. Abstract Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1 Fo ATP synthase and four
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24.05.2023

The long-loop recycling (LLR) of synaptic components as a question of economics

Authors Georgiev SV, Rizzoli SO Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2023 May 24;126:103862. Abstract The pre- and post-synaptic compartments contain a variety of molecules that are known to recycle between the plasma membrane and intracellular organelles. The recycling steps have been amply described in functional terms,
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24.05.2023

Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Authors Haro-Moreno JM, López-Pérez M, Alekseev A, Podoliak E, Kovalev K, Gordeliy V, Stepanauskas R, Rodriguez-Valera F Journal mSystems Citation mSystems. 2023 May 24:e0000823. Abstract Microbial rhodopsins are found more than once in a single genome (paralogs) often have different functions. We screened a large dataset of open ocean single-amplified
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22.05.2023

Modulating Secondary Structure Motifs through Photo-labile Peptide Staples

Authors Lāce I, Bazzi S, Uranga J, Schirmacher A, Diederichsen U, Mata RA, Simeth NA Journal ChemBioChem Citation Chembiochem. 2023 May 22:e202300270. Abstract Peptide-protein interactions (PPIs) are facilitated by the well-defined three-dimensional structure of bioactive peptides, interesting compounds for the development of new therapeutic agents. Their secondary structure and thus
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11.05.2023

Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography

Authors Reichmann J, Verleden SE, Kühnel M, Kamp JC, Werlein C, Neubert L, Müller JH, Bui TQ, Ackermann M, Jonigk D, Salditt T Journal Physics in Medicine and Biology Citation Phys Med Biol. 2023 May 11. Abstract As the central organ of the respiratory system, the human lung is responsible
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08.05.2023

Defining the Riddle in Order to Solve It: There Is More Than One „Parkinson’s Disease“

Authors Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ Journal Movement Disorders Citation Mov Disord. 2023 May 8. Abstract Background: More than 200 years
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02.05.2023

The genetic spectrum of congenital ocular motor apraxia type Cogan: an observational study, continued

Authors Schröder S, Yigit G, Li Y, Altmüller J, Büttel HM, Fiedler B, Kretzschmar C, Nürnberg P, Seeger J, Serpieri V, Valente EM, Wollnik B, Boltshauser E, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2023 May 2;18(1):101. Abstract Background: The term congenital ocular motor
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