Latest Publications

Authors Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(16), 12607. Abstract Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without

Authors Jain S, Koziej L, Poulis P, Kaczmarczyk I, Gaik M, Rawski M, Ranjan N, Glatt S, Rodnina MV Journal Nature Communications Citation Nat Commun. 2023 Aug 8;14(1):4784. Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding

Authors Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7:166835. Abstract Different SOD1 proteoforms are implicated## in both familial and sporadic cases of Amyotrophic Lateral Sclerosis

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are

Authors Chopra A, Outeiro TF Journal Brain Citation Brain. 2023 Aug 1:awad260. Abstract Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‚Lewy bodies‘ and ‚Lewy neurites‘. Together with dementia with Lewy

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a

Authors Zelená A, Blumberg J, Probst D, Gerasimaitė R, Lukinavicius G, Schwarz US, Köster S Journal Biophysical Journal Citation Biophys J. 2023 Jul 19:S0006-3495(23)00461-7. Abstract Blood platelets are central elements of the blood clotting response after wounding. Upon vessel damage, they bind to the surrounding matrix and contract the forming

Authors Pohlmann M, Werner F, Munk A Journal Information and Inference: A Journal of the IMA Citation Information and Inference: A Journal of the IMA, Volume 12, Issue 3, September 2023, iaad026. Abstract We investigate minimax testing for detecting local signals or linear combinations of such signals when only indirect

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of

Authors Markus MA, Ferrari DP, Alves F, Ramos-Gomes F Journal Biomedical Optics Express Citation Biomed. Opt. Express 14, 3988-4002 (2023). Abstract Fixation methods such as formalin are commonly used for the preservation of tissue with the aim of keeping their structure as close as possible to the native condition. However,