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03.04.2024

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

Authors López-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H   Journal Proceedings of the National Academy of Sciences of the United States of America   Citation Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320505121.   Abstract The presynaptic
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29.03.2024

Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation

Authors Maurer W, Rebs S, Köhne S, Eberl H, Wollnik B, Zibat A, Streckfuss-Bömeke K Journal Stem Cell Research Citation Stem Cell Res. 2024 Mar 29;77:103409. Abstract Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to
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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on
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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J   Journal Nature   Citation Nature. 2024 Apr;628(8006):145-153.   Abstract As hippocampal neurons respond to diverse types
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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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22.03.2024

Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures

Authors Shvachiy L, Amaro-Leal Â, Machado F, Rocha I, Outeiro TF, Geraldes V Journal Biomedicines Citation Biomedicines. 2024 Mar 22;12(4):711. Abstract Lead exposure is a significant health concern, ranking among the top 10 most harmful substances for humans. There are no safe levels of lead exposure, and it affects multiple
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20.03.2024

[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brain

Authors Saw RS, Buss S, Schmidt F, Ryazanov S, Leonov A, Kuebler L, Bleher D, Papadopoulos I, Roeben B, Schmidt F, Reimold M, Bonanno F, Grotegerd AK, Ruf V, Dahl B, Sandiego C, Henry K, Fehrenbacher B, Schaller M, Kahle P, Gasser T, Brockmann K, Reischl G, la Fougère C,
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20.03.2024

METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

Authors Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y   Journal Cell Death & Disease   Citation Cell Death Dis 15, 229 (2024).   Abstract Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging
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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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