Scientific Reports

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.

Authors Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF Journal Nature Protocols Citation Nat Protoc. 2019 Dec;14(12):3333-3365. Abstract Proteins are continually produced and degraded, to avoid the accumulation of old or damaged molecules and to maintain the efficiency of physiological processes. Despite its importance, protein turnover

Authors Stephan T, Roesch A, Riedel D, Jakobs S Journal Scientific Reports Citation Sci Rep. 2019 Aug 27;9(1):12419. Abstract Mitochondria are highly dynamic organelles that exhibit a complex inner architecture. They exhibit a smooth outer membrane and a highly convoluted inner membrane that forms invaginations called cristae. Imaging cristae in

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs