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07.01.2021

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf
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05.01.2021

Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea

Authors Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H Journal Cell Reports Citation Cell Rep. 2021 Jan 5;34(1):108551. Abstract Recent studies reveal great diversity in the structure, function, and efferent innervation of afferent synaptic connections between the cochlear inner hair
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05.01.2021

Role of GTPases in Driving Mitoribosome Assembly

Authors Maiti P, Lavdovskaia E, Barrientos A, Richter-Dennerlein R Journal Trends in Cell Biology Citation Trends Cell Biol. 2021 Jan 5:S0962-8924(20)30254-3. Abstract Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant
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01.01.2021

JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: Mitochondrial protection and antioxidant properties

Authors Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y Journal Neurotoxicology Citation Neurotoxicology. 2021 Jan;82:89-98. Abstract We have previously shown that JM-20, a new chemical entity consisting of 1,5-benzodiazepine fused to a
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28.12.2020

[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates

Authors Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K Journal European Journal of Nuclear Medicine and Molecular Imaging Citation Eur J Nucl Med Mol Imaging. 2020 Dec 28.
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24.12.2020

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Authors Lohrberg M, Winkler A, Franz J, van der Meer F, Ruhwedel T, Sirmpilatze N, Dadarwal R, Handwerker R, Esser D, Wiegand K, Hagel C, Gocht A, König FB, Boretius S, Möbius W, Stadelmann C, Barrantes-Freer A Journal Acta Neuropathologica Communications Citation Acta Neuropathol Commun. 2020 Dec 24;8(1):224. Abstract Demyelinated
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23.12.2020

Integrator is a genome-wide attenuator of non-productive transcription

Authors Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH Journal Molecular Cell Citation Mol Cell. 2020 Dec 23:S1097-2765(20)30906-0. Abstract Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator
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22.12.2020

Single-Cell Optical Action Potential Measurement in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Authors Seibertz F, Reynolds M, Voigt N Journal Journal of Visualized Experiments Citation J Vis Exp. 2020 Dec 22;(166). Abstract Conventional intracellular microelectrode techniques to quantify cardiomyocyte electrophysiology are extremely complex, labor intensive, and typically carried out in low throughput. Rapid and ongoing expansion of induced pluripotent stem cell (iPSC)
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21.12.2020

A sensory cell diversifies its output by varying Ca2+ influx-release coupling among active zones

Authors Özcete Ö, Moser T Journal EMBO Journal Citation EMBO J (2020)e106010. Abstract The cochlea encodes sound pressures varying over six orders of magnitude by collective operation of functionally diverse spiral ganglion neurons (SGNs). The mechanisms enabling this functional diversity remain elusive. Here, we asked whether the sound intensity information,
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21.12.2020

Cancer and Parkinson’s Disease: Common Targets, Emerging Hopes

Authors Filippou PS, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2020 Dec 21. Abstract Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. At first sight, the two fields do not seem to share much in common and, if anything, might be placed on opposite
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