Journal

Authors Sant’Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D Journal Molecular Medicine Citation Mol Med. 2023 Aug 18;29(1):111. Abstract Background: Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to

Authors Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K Journal Nature Citation Nature. 2023 Aug 16. Abstract The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When

Authors Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C Journal Frontiers in Cell and Developmental Biology Citation Front. Cell Dev. Biol., 10 August 2023. Abstract In mammals,

Authors Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(16), 12607. Abstract Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without

Authors Jain S, Koziej L, Poulis P, Kaczmarczyk I, Gaik M, Rawski M, Ranjan N, Glatt S, Rodnina MV Journal Nature Communications Citation Nat Commun. 2023 Aug 8;14(1):4784. Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding

Authors Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA Journal Biochimica et Biophysica Acta – Molecular Basis of Disease Citation Biochim Biophys Acta Mol Basis Dis. 2023 Aug 7:166835. Abstract Different SOD1 proteoforms are implicated## in both familial and sporadic cases of Amyotrophic Lateral Sclerosis

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are

Authors Chopra A, Outeiro TF Journal Brain Citation Brain. 2023 Aug 1:awad260. Abstract Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‚Lewy bodies‘ and ‚Lewy neurites‘. Together with dementia with Lewy

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a

Authors Zelená A, Blumberg J, Probst D, Gerasimaitė R, Lukinavicius G, Schwarz US, Köster S Journal Biophysical Journal Citation Biophys J. 2023 Jul 19:S0006-3495(23)00461-7. Abstract Blood platelets are central elements of the blood clotting response after wounding. Upon vessel damage, they bind to the surrounding matrix and contract the forming