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10.07.2025

Nucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13

Authors Kloskowski P, Neumann P, Berndt A, Ficner R Journal Acta Crystallographica Section F-Structural Biology Communications Citation Acta Crystallogr F Struct Biol Commun. 2025 Aug 1. Abstract Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures
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10.07.2025

Structural basis for no retinal binding in flotillin-associated rhodopsins

Authors Kovalev K, Stetsenko A, Trunk F, Marin E, Haro-Moreno JM, Lamm GHU, Alekseev A, Rodriguez-Valera F, Schneider TR, Wachtveitl J, Guskov A Journal Structure Citation Structure. 2025 Jul 10:S0969-2126(25)00222-9. Abstract Rhodopsins are light-sensitive membrane proteins capturing solar energy via a retinal cofactor covalently attached to a lysine residue. Several
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08.07.2025

FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites

Authors Antonicka H, Vučković A, Weraarpachai W, Hong S, Brischigliaro M, Ahn A, Barrientos A, Hillen HS, Shoubridge EA Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jul 8;53(13):gkaf665. Abstract The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in
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04.07.2025

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Alekseev A, Schellbach AV, Stetsenko A, Haro-Moreno JM, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Rodriguez-Valera F, Wachtveitl J, Guskov A, Kovalev K Journal Science Advances Citation Sci
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03.07.2025

Lamin variants cause cardiac arrhythmogenicity in Drosophila

Authors van Wijk SW, Vree P, Huiskes FG, van der Palen RL, Liutkute A, Voigt N, Wallrath LL, Brundel BJJM Journal Disease Models and Mechanism Citation Dis Model Mech. 2025 Jul 3:dmm.052424. Abstract Atrial fibrillation (AF), the most common progressive cardiac arrhythmia, is associated with serious complications such as stroke
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01.07.2025

Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems

Authors Jakob L, van der Wal JJ, Tovtik R, Copko J, Iagatti A, Donato MD, Crespi S, Simeth NA Journal Chemistry – A European Journal Citation Chemistry. 2025 Jul 1:e202501856. Abstract Photoswitches have been impacting diverse areas of research, introducing means of dynamically regulating their environment through reversible photochemical isomerization.
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21.06.2025

Testosterone and atrial fibrillation: does the dose make the poison?

Authors Mason FE, Liutkute A, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2025 Jun 21:cvaf113. Abstract No abstract available. DOI 10.1093/cvr/cvaf113   Pubmed Link
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20.06.2025

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

Authors Gather F, Rauleac T, Akol I, Arumugam G, Fullio CL, Müller T, Kleidonas D, Geiss-Friedlander R, Fischer A, Vlachos A, Backofen R, Vogel T Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jun 20;53(12):gkaf539. Abstract Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and
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18.06.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025 Jun 20;11(25):eadu7898. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
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12.06.2025

Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure

Authors Gisa V, Islam MR, Lbik D, Hofmann RM, Pena T, Krüger DM, Burkhardt S, Schütz AL, Sananbenesi F, Toischer K, Fischer A Journal Non-coding RNA Citation Noncoding RNA. 2025 Jun 12;11(3):45. Abstract Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet
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