2026 – Seite 4

25.03.2026

lncRNA Glelr modulates microglia inflammatory programs in association with PU.1

Authors Pradhan R, Sakib MS, Kaurani L, Krüger DM, Pena T, Burkhardt S, Schütz AL, Kronenberg-Versteeg D, Delalle I, Sananbenesi F, Fischer A Journal Neurobiology of Disease Citation Neurobiol Dis. 2026 Mar 25;222:107366. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to

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24.03.2026

A correlative workflow for synaptic imaging by cryo-electron tomography

Authors Do TT, Siegert A, Domart F, Hahn F, Zeising C, Muth S, Pape C, Kusch K, Dresbach T, Rizzoli SO, Petrovic A, Fernández-Busnadiego R Journal Structure Citation Structure. 2026 Mar 24:S0969-2126(26)00059-6. Abstract Despite decades of intense research, the molecular organization of the synapse is not well understood. To address

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23.03.2026

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

Authors Mukhopadhyay M, Modgekar R, Yang-Hood A, Ohlemiller KK, Militchin V, Xiao M, Shen Z, Rensing NR, Wong M, Lee SJ, Seal RP, Holt JC, Warchol ME, Maloney SE, Yuede CM, Rutherford MA, Pangrsic T Journal Scientific Reports Citation Sci Rep. 2026 Mar 23. Abstract Quantal synaptic transmission in vestibular

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20.03.2026

Evaluating Vision Foundation Models for Pixel and Object Classification in Microscopy

Authors Teuber C, Archit A, Boothe T, Ditte P, Rink J, Pape C Journal Arxiv Citation arXiv:2603.19802. Abstract Deep learning underlies most modern approaches and tools in computer vision, including biomedical imaging. However, for interactive semantic segmentation (often called pixel classification in this context) and interactive object-level classification (object classification),

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19.03.2026

Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Authors Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T, Ecker AS Journal eNeuro Citation eNeuro. 2026 Mar 19:ENEURO.0060-26.2026. Abstract The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, and

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18.03.2026

Leopoldina zeichnet Biochemikerin Melina Schuh mit der Carus-Medaille aus

Um Paare mit unerfülltem Kinderwunsch unterstützen zu können, muss die Herausbildung der menschlichen Keimzellen genau verstanden werden. Die Biochemikerin und MBExC Mitglied Melina Schuh erforscht die Entwicklung von Säugetier-Eizellen und fand heraus, wieso es zu Fehlern bei der Eizellbildung kommen kann. Hierfür würdigt sie die Nationale Akademie der Wissenschaften Leopoldina

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18.03.2026

Revisiting foundation models for cell instance segmentation

Authors Archit A, Pape C Journal Arxiv Citation arXiv:2603.17845. Abstract Cell segmentation is a fundamental task in microscopy image analysis. Several foundation models for cell segmentation have been introduced, virtually all of them are extensions of Segment Anything Model (SAM), improving it for microscopy data. Recently, SAM2 and SAM3 have

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17.03.2026

Myosin II-driven contractions of supporting cap cells promote sensory adaptation of Drosophila proprioceptors

Authors Guan C, Nishi K, Kreis CT, Bäumchen O, Göpfert MC, Schmidt CF Journal Current Biology Citation Curr Biol. 2026 Mar 17:S0960-9822(26)00223-X. Abstract Mechanoreceptors can be motile and actively amplify their mechanical input.1,2,3,4 We here found that the responses of mechanoreceptor cells can also be shaped actively by contractile supporting

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17.03.2026

Early demyelination by off-target complement injury in a mouse model of neuromyelitis optica

Authors Kenet S, Herwerth M, Askari S, Eichenseer K, Dornmair K, Qin X, Stadelmann C, Bennett JL, Hemmer B, Misgeld T Journal BioRxiv Citation bioRxiv 2026.03.13.711636. Abstract Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune CNS disease characterized by serum antibodies targeting astrocytes for complement-mediated lysis. NMOSD lesions show not

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16.03.2026

Hochauflösende Elektronenmikroskopie zeigt, wie Zellen mit Stress umgehen

Ein internationales Team unter Leitung von Forschenden der Universitätsmedizin Göttingen (UMG) hat mithilfe modernster elektronenmikroskopischer Technologien wichtige zelluläre Mechanismen der Stressresistenz mit nahezu atomarer Auflösung sichtbar gemacht. Die Forschenden haben gezeigt, dass das Protein mHsp60, das anderen Proteinen hilft, ihre funktionelle Form anzunehmen, seine Struktur unter Stressbedingungen so verändert, dass

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