12.03.2026
Authors Folarin RO, Olopade FE, Gilbert TT, Ladagu AD, Dos Santos PIP, Mustapha OA, Kpasham LZ, Outeiro TF, Olopade JO Journal Metabolic Brain Disease Citation Metab Brain Dis. 2026 Mar 12;41(1):52. Abstract Vanadium, an environmental pollutant, is closely associated with neurodegeneration, primarily through oxidative damage and chronic neuroinflammation. While chronic
10.03.2026
Mitotic BLM functions are required to maintain genomic stability
Authors Hamann TE, Wieland A, Mohseni F, Vukušić K, Tirincsi A, Wardenaar R, Losito M, Harmsen I, Gönenc II, Wollnik B, Foijer F, Tolić IM, Storchová Z, Räschle M Journal Nucleid Acid Research Citation Nucleic Acids Res. 2026 Feb 24;54(5):gkag199. Abstract The BLM helicase is a critical genome maintenance protein
10.03.2026
Visualizing the multidimensional landscape of biological variation in modern microscopy
Authors Müller GF, Göpel T, Scherf N, Huisken J. Journal Frontiers in Bioinformatics Citation Front Bioinform. 2026 Mar 10;6:1757489. Abstract Variation is a foundational biological principle that has historically been marginalized-both due to limited experimental accessibility and because of idealized, stereotypic blueprints rooted in essentialist thinking. With the advent of
09.03.2026
Arousal elicits a brain-wide hemodynamic wave independent of locus coeruleus noradrenergic tone
Authors Martinez de Paz JM, Mayer JL, Wanken P, Rodrigues Apgaua B, Ablitip A, Behera L, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.710089. Abstract Arousal fluctuations during wakefulness have a major impact on physiology and behavior, including perception and task performance. Arousal is also known to be a strong modulator
09.03.2026
Image modifications reduce differences in natural-image encoding by retinal ganglion cells between natural and optogenetic stimulation
Authors Ramakrishna V, Gollisch T Journal BioRxiv Citation bioRxiv 2026.03.06.710066. Abstract Photoreceptor degeneration is among the leading causes of blindness and optogenetics as a potential therapeutic measure has garnered much attention over recent years. In this approach, light-sensitive molecules like Channelrhodopsin-2 (ChR2) are inserted into neurons in the retina to
06.03.2026
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Authors Ehses K, López-Alonso JP, Antico O, Azem A, Muqit MMK, Ubarretxena-Belandia I, Fernández-Busnadiego R Journal Science Advances Citation Sci Adv. 2026. Sci Adv. 2026 Mar 6;12(10):eaed3579. Abstract Cells have evolved organelle-specific responses to maintain protein homeostasis (proteostasis). During proteostatic stress, mitochondria down-regulate translation and enhance protein folding, yet the
06.03.2026
A transition-prone brain state precedes spontaneous behavioral switching
Authors Wanken P, Edelman BJ, Behera L, Martinez de Paz JM, McCarthy PT, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.709845. Abstract Animals exhibit behavior in the absence of external stimuli or explicit tasks. Is the initiation of such spontaneous behavior shaped by internal brain states in a predictable manner? If
03.03.2026
Präzisionsmedizin für seltene Herzerkrankung
Göttinger Forschung erhält Millionenförderung Mit einem Gentherapieprojekt zur Behandlung des Noonan-Syndroms erhält die Universitätsmedizin Göttingen (UMG) über eine Million Euro aus dem Förderprogramm zukunft.niedersachsen. Im Fokus steht die Entwicklung individuell zugeschnittener Therapien für herzkranke Kinder. Seltene Erkrankungen stellen Betroffene und ihre Familien häufig vor große medizinische Herausforderungen: Die
03.03.2026
Kleine Strömungen, große Erkenntnisse: Mikrofluidik-System verbessert Superauflösungsmikroskopie
Internationales Forschungsteam verbessert Bildgebung vom komplexen Inneren der Zellen Wie sind Zellen organisiert? Und wie arbeiten ihre molekularen Bestandteile zusammen? Das zu verstehen, ist ein zentrales Ziel moderner Life Sciences. Forschende müssen dabei viele Strukturen in einer Zelle gleichzeitig betrachten, um zu erkennen, wie sie angeordnet sind und interagieren.
03.03.2026
Mechanism of human tRNA 3′CCA maturation
Authors Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen H Journal BioRxiv Citation bioRxiv 2026.03.02.709036. Abstract The non-templated addition of the 3′CCA end is the final universal step of tRNA maturation. In humans, 3′CCA addition on nuclear- (nu-tRNA) and mitochondria-encoded tRNAs (mt-tRNA) is catalyzed by a single




