2025

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15.04.2025

D-amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection.

Authors Maurer W, Zieseniss A, Priya VP, Chen Y, Bauer L, Hillemann A, Rehling P, Nanadikar MS, de Zélicourt D, Kurtcuoglu V, Katschinski DM Journal British Journal of Pharmacology Citation Br J Pharmacol. 2025 Apr 15. Abstract Background and purpose: D-amino acid oxidase (DAO) has been developed as a chemogenetic
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14.04.2025

Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study

Authors Galbusera R, Weigel M, Bahn E, Schaedelin S, Cagol A, Lu PJ, Barakovic M, Melie-Garcia L, Franz J, Dechent P, Nair G, Kappos L, Brück W, Stadelmann C, Granziera C Journal Brain Pathology Citation Brain Pathol. 2025 Apr 14:e70010. Abstract Remyelination of cortical lesions in people with multiple sclerosis
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13.04.2025

Differentiation of Mature Dopaminergic Neurons from Human Induced Pluripotent Stem Cells

Authors Garg P, Bähr M, Kügler S Journal Methods in Molecular Biology (Clifton, N.J.) Citation Methods Mol Biol. 2025;2910:53-68. Abstract Reprogramming of somatic cells like blood cells and fibroblasts to obtain human induced pluripotent stem cells (hiPSCs) has become a state-of-the-art tool to study human diseases. The self-renewable hiPSCs offer
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11.04.2025

A role for astrocytic miR-129-5p in frontotemporal dementia

Authors Kaurani L, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Krüger DM, Pena T, Heutink P, Sananbenesi F, Fischer A Journal Translational Psychiatry Citation Transl Psychiatry. 2025 Apr 11;15(1):142. Abstract Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language
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11.04.2025

Distinct transmission sites within a synapse for strengthening and homeostasis

Authors Yang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM Journal Science Advances Citation Sci Adv. 2025 Apr 11;11(15):eads5750. Abstract At synapses, miniature synaptic transmission forms the
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08.04.2025

Stamped counting for biomedical images

Authors Jeremias J, Pape C Journal Methods in Microscopy Citation Methods in Microscopy, 2025. Abstract Counting objects is an important task in biomedical image analysis, for example to count cells in microscopy or microbial colonies in laboratory applications. Similar to most image analysis tasks, modern approaches to counting rely on
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08.04.2025

Understanding inherited cardiomyopathies: clinical aspects and genetic determinants

Authors Yigit G, Kaulfuß S, Wollnik B Journal Medizinische Genetik Citation Med Genet. 2025 Apr 8;37(2):103-111. Abstract Cardiomyopathies (CMs) are a clinically heterogeneous group of cardiovascular diseases characterized by structural and functional abnormalities of the heart muscle in the absence of coronary artery disease, hypertension, valve disease, or congenital heart
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Beteiligungsvertrag zwischen Bioventure und Repairon (v. l. n. r.): Akos Farkas (Bioventure), Nico Straub (Partner Bioventure), Dr. Lothar Germeroth, Dr. Erik Hoppe (Geschäftsführer Bioventure), Prof. Dr. Wolfram-Hubertus Zimmermann (UMG). Foto: Kay Kirchwitz

07.04.2025

Wegweisende Partnerschaft für die Zukunft der regenerativen Herzmedizin

Mit der Unterzeichnung eines Beteiligungsvertrags am 2. April 2025 haben die Göttinger Biotechnologiepioniere Repairon GmbH und der Life Science-Investor Bioventure Management GmbH eine strategische Partnerschaft besiegelt, die das Potenzial hat, die Behandlung von Herzinsuffizienz weltweit grundlegend zu verändern. Bioventure beteiligt sich als Investor an Repairon – einer Ausgründung der Universitätsmedizin
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07.04.2025

Modulation of protein activity by small RNA base pairing internal to coding sequences

Authors Thongdee N, Alaniz MM, Samatova E, Zhong A, Esnault C, Zhang H, Dale RK, Rodnina MV, Storz G Journal Molecular Cell Citation Mol Cell. 2025 Mar 30:S1097-2765(25)00258-8. Abstract Most characterized interactions between bacterial small RNAs (sRNAs) and their target mRNAs occur near ribosome binding sites, resulting in changes in
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04.04.2025

Recent developments in multiple sclerosis neuropathology

Authors Stadelmann C, Franz J, Nessler S Journal Current Opinion in Neurology Citation Curr Opin Neurol. 2025 Apr 4. Abstract Purpose of review: Neuropathological studies in human brain tissue are indispensable for our understanding of disease mechanisms in multiple sclerosis (MS). They inform concepts of lesion evolution, tissue regeneration and
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