2025

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24.04.2025

Internationaler Tag des Versuchstieres

110 Wissenschaftlerinnen und Wissenschaftler bekennen sich klar zur tierexperimentellen Forschung: „Wir machen Tierversuche!“   Anlässlich des Internationalen Tages des Versuchstieres am 24. April 2025 bekennen sich 110 führende Wissenschaftlerinnen und Wissenschaftler aus Deutschland (darunter auch MBExC Mitglieder) öffentlich zu ihrer tierexperimentellen Forschung. Unter dem gemeinsamen Statement „Wir machen Tierversuche!“ machen
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23.04.2025

Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading

Authors Preobraschenski J, Kreutzberger AJB, Ganzella M, Münster-Wandowski A, Kreutzberger MAB, Oolsthorn LHM, Seibert S, Kiessling V, Riedel D, Witkowska A, Ahnert-Hilger G, Tamm LK, Jahn R Journal Science Advances Citation Sci Adv. 2025 Apr 25;11(17):eads4661. Abstract Synaptic transmission is mediated by the exocytotic release of neurotransmitters stored in synaptic
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23.04.2025

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Authors Harris SS, Ellingford R, Hartmann J, Dasgupta D, Kehring M, Rajani RM, Graykowski D, Quittot N, Sivasankaran D, Commins C, Fan Z, Bond SA, Wolf F, Dupret D, Dolan RJ, Konnerth A, Neef A, Hyman BT, Busche MA Journal Cell Citation Cell. 2025 Apr 23:S0092-8674(25)00408-8. Abstract Tau accumulation is
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23.04.2025

Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders

Authors Solomon P, Kaurani L, Budde M, Guiné JB, Krüger DM, Riquin K, Pena T, Burkhardt S, Fourgeux C, Adorjan K, Heilbronner M, Kalman JL, Kohshour MO, Papiol S, Reich-Erkelenz D, Schaupp SK, Schulte EC, Senner F, Vogl T, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter
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22.04.2025

BTRR complex deficiency is a driver for genomic instability in Bloom syndrome

Authors Gönenc II, Wolff A, Busley AV, Wieland A, Tijhuis A, Müller C, Wardenaar R, Argyriou L, Kaulfuß S, Räschle M, Spierings DCJ, Foijer F, Bastians H, Yigit G, Zibat A, Cyganek L, Wollnik B Journal BioRxiv Citation bioRxiv 2025.04.17.649287. Abstract Biallelic loss-of-function (LoF) variants in the BTRR complex members
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22.04.2025

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils

Authors Kim M, Matthes D, Frieg B, Leonov A, Ryazanov S, Bleher D,Grotegerd AK, Dienemann C, Giese A, Schröder GF, Becker S, Herfert K, de Groot BL, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.04.21.649837. Abstract Accumulation of α-synuclein (αSyn) aggregates in the human brain is the major hallmark
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18.04.2025

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport

Authors Bukhdruker S, Gushchin I, Shevchenko V, Kovalev K, Polovinkin V, Tsybrov F, Astashkin R, Alekseev A, Mikhaylov A, Bukhalovich S, Bratanov D, Ryzhykau Y, Kuklina D, Caramello N, Rokitskaya T, Antonenko Y, Rulev M, Stoev C, Zabelskii D, Round E, Rogachev A, Borshchevskiy V, Ghai R, Bourenkov G, Zeghouf
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18.04.2025

Profiling the LAM family of contact site tethers provides insights into their regulation and function

Authors Fenech EJ, Kupervaser M, Boshnakovska A, Ravid S, Gomes Castro I, Asraf Y, Callegari S, Lenz C, Urlaub H, Rehling P, Schuldiner M Journal Contact (Thousand Oaks) Citation Contact (Thousand Oaks). 2025 Apr 17;8:25152564251321770. Abstract Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins
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17.04.2025

Coupling of ribosome biogenesis and translation initiation in human mitochondria

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we
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15.04.2025

Synchronization in epithelial tissue morphogenesis

Authors Richa P, Häring M, Wang Q, Choudhury AR, Göpfert MC, Wolf F, Großhans J, Kong D Journal Current Biology Citation Curr Biol. 2025 Apr 11:S0960-9822(25)00382-3. Abstract Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape
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