2024

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20.08.2024

Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

Authors Zapp SJ, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Krueppel S, Mietsch M, Protti DA, Karamanlis D, Gollisch T Journal eLife Citation eLife13:RP99945. Abstract A standard circuit motif in sensory systems is the pooling of sensory information from an upstream neuronal layer. A downstream neuron thereby collects signals
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19.08.2024

Stochastic tug-of-war among sarcomeres mediates cardiomyocyte response to environmental stiffness

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Zimmermann WH, Schmidt CF Journal eLife Citation eLife 13:RP97321. Abstract Cardiac muscle function emerges from the coordinated contraction of sarcomeres in cardiomyocytes. Sarcomere dynamics are usually inferred from whole-cell or myofibril observations, assuming synchronized, uniform behavior. Here, we investigated how different
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12.08.2024

Morphological correlates of synaptic protein turnover in the mouse brain

Authors Li F, Bahr JN, Bierth FA, Reshetniak S, Tetzlaff C, Fornasiero EF, Wichmann C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2024 Aug 12;7(11):e202402793. Abstract Synaptic proteins need to be replaced regularly, to maintain function and to prevent damage. It is unclear whether this process, known
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12.08.2024

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Authors Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco
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11.08.2024

Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase

Authors Rotsch AH, Li D, Dupont M, Krischuns T, Oberthuer C, Stelfox A, Lukarska M, Fianu I, Lidschreiber M, Naffakh N, Dienemann C, Cusack S, Cramer P Journal BioRxiv Citation bioRxiv 2024.08.11.607481. Abstract Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′
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07.08.2024

Visible and near-infrared light-induced photoclick reactions

Authors Fu Y, Simeth NA, Szymanski W, Feringa BL Journal Nature Reviews Chemistry Citation Nat Rev Chem. 2024 Aug 7. Abstract Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer
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06.08.2024

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal BioRxiv Citation bioRxiv 2024.08.02.606323. Abstract Vesicle exocytosis is a fundamental component of intercellular communication, in all organisms. It has been studied for decades, using
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06.08.2024

A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies

Authors Amaral L, Mendes F, Côrte-Real M, Rego A, Outeiro TF, Chaves SR Journal Chemosphere Citation Chemosphere. 2024 Aug 6:143039. Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein
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05.08.2024

Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation

Authors Kim R, Nagel SH, Liaw NY, Zimmermann WH, Zelarayan LC, Schoger E Journal Stem Cell Research Citation Stem Cell Research (2024). Abstract The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived
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Schematische Darstellung des hoch empfindlichen Detektors. Dieser besteht aus 23 einzelnen Detektoren, wodurch die Auflösung des Fluoreszenzmikroskops verdoppelt werden konnte. Foto: Alexey Chizhik, Universität Göttingen

02.08.2024

Blick in die Nanowelt: Neues Mikroskop enthüllt feinste Zellprozesse

Forscherteam mit Göttinger Beteiligung entwickelt hochauflösendes Fluoreszenzmikroskop   Wie sieht das Innere einer Zelle wirklich aus? Bisherige Mikroskope stoßen bei dieser Frage oft an ihre Grenzen. Nun ist es Forschenden der Universitäten Göttingen und Oxford in Zusammenarbeit mit der Universitätsmedizin Göttingen gelungen, ein Mikroskop mit Auflösungen von besser als fünf
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